937690-59-0

Basic information

• Product Name: 3-AMINO-N-(PROPAN-2-YL)PROPANAMIDE
• Synonyms: 3-AMINO-N-(PROPAN-2-YL)PROPANAMIDE;3-Amino-N-isopropyl-propionamide
• CAS NO: 937690-59-0
• Molecular Formula: C6H14N2O
• Molecular Weight: 130.18816
• Mol File: 937690-59-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-AMINO-N-(PROPAN-2-YL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-(PROPAN-2-YL)PROPANAMIDE(937690-59-0)
• EPA Substance Registry System: 3-AMINO-N-(PROPAN-2-YL)PROPANAMIDE(937690-59-0)

Safety Data

• Hazardous Substances Data: 937690-59-0(Hazardous Substances Data)

Relevant articles and documents

Methylene C(sp3)-H β,β′-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand

A hindered β-amino amide transient directing group effects di-trans-arylation of cyclohexanecarbaldehydes. The amide N-substituents are shown to affect yield and can enhance the rate of arylation compared with the α-amino acid. Addition of a pyridone ligand further enhanced reactivity. The reaction is successful for a range of aryl iodides, and various substituted cyclohexane carboxaldehydes, providing functionalized products from simple feedstocks. A mechanism is proposed evoking a transient enamine.

Palladium-catalyzed β-C-H arylation of aliphatic aldehydes and ketones using amino amide as a transient directing group

This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.

Palladium-Catalyzed β-C?H Arylation of Ketones Using Amino Amide as a Transient Directing Group: Applications to Synthesis of Phenanthridinone Alkaloids

The direct arylation of aromatic and aliphatic ketones was carried out via palladium-catalyzed inert C?H bond functionalization with 2-amino-N-isopropyl-acetamide as a new catalytic transient directing group. The reaction showed excellent functional group compatibility and site selectivity. We demonstrated that α-amino amide forming N,N-bidentate coordination with Pd catalyst is more favorable for the β-arylation of ketones than α-amino acid forming N,O-bidentate coordination with Pd catalyst under relatively mild conditions. This elegant approach provides straightforward access to important structural motifs in organic and medicinal chemistry and is demonstrated here in the efficient synthesis of phenanthridinone alkaloids. (Figure presented.).