- MTA-Cooperative PRMT5 Inhibitors
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The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
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Paragraph 0302
(2021/03/19)
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- Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas
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A series of novel 3,4-disubstituted pyrazoles were synthesized. The cytotoxicity against U87MG glioma cell line have been investigated in vitro and three of these compounds showed promising inhibitory activity on cell growth with an IC50 lower
- Comes Franchini, Mauro,Bonini, Bianca Flavia,Camaggi, Carlo Maurizio,Gentili, Denis,Pession, Annalisa,Rani, Monica,Strocchi, Elena
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experimental part
p. 2024 - 2033
(2010/06/20)
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- Pyrazole-based ligands for the [copper-TEMPO]-mediated oxidation of benzyl alcohol to benzaldehyde and structures of the Cu coordination compounds
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New pyrazole-based ligands have been designed, and the catalytic performances of their copper(II) complexes for the [copper/TEMPO]-mediated oxidation of benzyl alcohol to benzaldehyde have been examined. The pyridine-pyrazole ligands give efficient catalysts, while the use of naphthol-pyrazole ligands results in inactive catalytic systems. Single-crystals of four Cu coordination compounds obtained from pyridine-pyrazole ligands and a free ligand have been isolated and were characterized by X-ray diffraction. Thus, the solid-state structures of three copper(II) complexes are described, together with a copper(I) coordination chain, exhibiting luminescent properties. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
- Uber, Jorge Salinas,Vogels, Yorick,Van Den Helder, Dave,Mutikainen, Ilpo,Turpeinen, Urho,Fu, Wen Tian,Roubeau, Olivier,Gamez, Patrick,Reedijk, Jan
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p. 4197 - 4206
(2008/03/14)
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- Indium-mediated synthesis of heterobiaryls
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The palladium-mediated coupling reaction between triorganoindium reagents and organic electrophiles is extended to the synthesis of heteroaromatic compounds. Both electron-rich and electron-poor heterocycles can act as the organic electrophile or as the organoindium derivative.
- Font-Sanchis, Enrique,Cespedes-Guirao, F. Javier,Sastre-Santos, Angela,Fernandez-Lazaro, Fernando
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p. 3589 - 3591
(2008/02/04)
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