Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols
A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan- 1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4?7 ?M) was greatest for the cyclohexyl and cyclopentyl analogues. CSIRO 2006.
Kerr, David I. B.,Khalafy, Jabbar,Ong, Jennifer,Perkins, Michael V.,Prager, Rolf H.,Puspawati, Ni Made,Rimaz, Mehdi
p. 457 - 462
(2007/10/03)
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