- Synthesis of programmable tetra-ortho-substituted biaryl compounds using Diels-Alder cycloadditions/cycloreversions of disubstituted alkynyl stannanes
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Orthogonally functionalized, programmable biaryl templates have been synthesized utilizing aryl acetylenic stannanes and oxygenated dienes in a cycloaddition/cycloreversion strategy. Sequential functionalization of each of the four ortho positions has bee
- Perkins, Johanna R.,Carter, Rich G.
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p. 3290 - 3291
(2008/09/21)
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- Reactions of Trialkylsilyl Trifluoromethanesulfonates, III. - Synthesis of 1,3-Bis(trimethylsiloxy)-1,3-dienes and 3-Trimethylsiloxy-2-butenoates Silylated in Position 4
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Bis(trimethylsiloxy)-1,3-dienes 5a - n are obtained by reaction of 1,3-dicarbonyl compounds 1 with trimethylsilyl trifluoromethanesulfonate (2) in the presence of triethylamine (3).The silyl enol ether 8 is silylated by 2/3 to yield 1,3-bis(trimethylsiloxy)-1,3-butadiene (5o).Depending on the conditions, alkyl 3-oxobutanoates 12 react with 2/3 to give the γ-silylated alkyl 3-trimethylsiloxy-2-butenoates 15 or 16.
- Kraegeloh, Konrad,Simchen, Gerhard,Schweiker, Kurt
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p. 2352 - 2362
(2007/10/02)
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- A Convenient Synthesis of Hydroxyphthalides
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The Diels-Alder reaction of in situ generated cyclohexa-1,3-dienes with methyl 4,4-diethoxybut-2-ynoate (1) followed by reverse Diels-Alder and hydrolysis affords substituted hydroxyphthalides in good yield.
- Freskos, John,Cynkowski, Tadeusz,Swenton, John S.
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p. 819 - 820
(2007/10/02)
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