- Method for synthesizing felodipine intermediate 2,3-dichlorobenzaldehyde
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The invention discloses a method for synthesizing felodipine intermediate 2,3-dichlorobenzaldehyde. The method comprises the following steps: performing sulfonating, hydroformylation and de-sulfonation on o-dichlorobenzene to generate 2,3-dichlorobenzaldehyde; under the condition of a protonic acid, performing protonation and fracturing on urotropine to generate imine ions; using the imine ions toundergo electrophilic aromatic substitution on an aromatic ring and undergo tautomerism to generate a benzylamine derivative; performing secondary protonation and fracturing on the rest of urotropineto generate imine ions, and performing an intramolecular redox reaction to partially oxidize the benzylamine into benzylidene imine ions; and performing hydrolysis to obtain an aldehyde. The method has high selectivity, less pollution discharge and lower cost.
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Paragraph 0030; 0032; 0033; 0039; 0040; 0047; 0048
(2019/10/01)
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