- HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME
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Compound represented by formula (I): wherein each symbol is as defined herein, exhibit TRPA1 antagonist activity, and are useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.
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Paragraph 0309
(2015/10/28)
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- IMIDAZOLE CARBOXAMIDES
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The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.
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Page/Page column 14
(2010/02/17)
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- HETEROCYCLIC CONDENSED COMPOUNDS USEFUL AS ANTIDIURETIC AGENTS
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The invention concerns compounds according to general formulae 1, wherein G1 is an amine. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents.
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Page/Page column 19-20
(2010/10/20)
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- Non-peptide oxytocin agonists
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The first non-peptide, low molecular weight agonists of the hormone oxytocin (OT) are reported. The most potent compound, 39, showed an EC 50 = 33 nM and was selective for the OT receptor. A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).
- Pitt, Gary,Batt, Andrzej,Haigh, Robert,Penson, Andrew,Robson, Peter,Rooker, David,Tartar, André,Trim, Julie,Yea, Christopher,Roe, Michael
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p. 4585 - 4589
(2007/10/03)
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