94152-63-3Relevant articles and documents
Synthesis of (-)-homogalanthamine from naltrexone
Yamamoto, Naoshi,Fujii, Hideaki,Imaide, Satomi,Hirayama, Shigeto,Nemoto, Toru,Inokoshi, Junji,Tomoda, Hiroshi,Nagase, Hiroshi
, p. 2257 - 2260 (2011)
Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.