- Enantioselective Catalyst Systems from Copper(II) Triflate and BINOL–Silanediol
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Silanediol and copper catalysis are merged, for the first time, to create an enhanced Lewis acid catalyst system for enantioselective heterocycle functionalization. The promise of this silanediol and copper catalyst combination is demonstrated in the enantioselective addition of indoles to alkylidene malonates to give rise to the desirable adducts in excellent yield and high enantiomeric excess. From these studies, 1,1′-bi-2-naphthol (BINOL)-based silanediols emerge as one-of-a-kind cocatalysts. Their potential role in the reaction pathway is also discussed.
- Guan, Yong,Attard, Jonathan W.,Visco, Michael D.,Fisher, Thomas J.,Mattson, Anita E.
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supporting information
p. 7123 - 7127
(2018/05/08)
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- TiCl4 promoted formal [3 + 3] cycloaddition of cyclopropane 1,1-diesters with azides: Synthesis of highly functionalized triazinines and azetidines
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A TiCl4 promoted formal [3 + 3] cycloaddition of cyclopropane 1,1-diesters with azides has been developed for the synthesis of highly functionalized triazinines. Both stoichiometric and substoichiometric versions of this reaction were accomplished dependent on the choice of solvent. It is noteworthy that the corresponding products could be easily converted to biologically important azetidines by simple thermolysis.
- Zhang, Huan-Huan,Luo, Yong-Chun,Wang, Hua-Peng,Chen, Wei,Xu, Peng-Fei
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supporting information
p. 4896 - 4899
(2015/04/27)
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- Unsaturated esters
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The present invention relates to new α,β-unsaturated esters of formula I. The new compounds exhibit an intense, very long lasting fruity-pineapple odor with green galbanum-type undertones.
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- Synthetic studies on CP-225,917 and CP-263,114: Concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reaction
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A concise synthesis of the bicyclo[4.3.1]dec-1(9)-en-10-one core of the natural products CP-225,917 and CP-263,114 is reported, employing an intramolecular Mukaiyama aldol cyclisation as a key step.
- Armstrong, Alan,Critchley, Trevor J.,Gourdel-Martin, Marie-Edith,Kelsey, Richard D.,Mortlock, Andrew A.
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p. 1344 - 1350
(2007/10/03)
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- Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel
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Novel substituted amino acids of formula are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders
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- Reactions of diazocompounds with carbonyl compounds mediated by diorganyl telluride and catalytic amount of CuI compounds: Conversion of aldehydes to a
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A one-pot reaction of diorganyl telluride, diazo-compounds including dimethyl diazomalonate and ethyl diazoacetate, carbonyl compound and catalytic amount of Cu(I)I afforded the olefination products in high yields. The reaction is proposed to be through diorganyltelluronium bis (methoxycarbonyl)methylide and (ethoxycarbonyl)methylide respectively.
- Zhou, Zhang-Lin,Huang, Yao-Zeng,Shi, Li-Lan
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p. 6821 - 6830
(2007/10/02)
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- A novel olefination of carbonyl compounds with dibromo-malonate promoted by dibutyl telluride
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α,β-Unsaturated malonic esters are conveniently synthesized from the reaction of dibromomalonate with carbonyl compounds promoted by dibutyl telluride in excellent yields. A possible mechanism involving twice halophilic attacks of dibutyl telluride is proposed. This methodology provides a facile route to α,β-unsaturated malonic esters and represents an alternative to the Knoevenagel reaction.
- Zhou,Shi,Huang
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p. 1027 - 1037
(2007/10/02)
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- A novel olefination of diazo-compounds with carbonyl compounds mediated by tributylstibine and catalytic amount of Cu(I)I
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A one-pot reaction of tributylstibine, diazo-compounds including dimethyl diazomalonate, ethyl diazoacetate and diazoacetylacetone, carbonyl compounds and catalytic amount of Cu(I)I resulted in olefination in high yields.
- Liao,Huang
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p. 5897 - 5900
(2007/10/02)
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