942922-07-8

Basic information

• Product Name: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER
• Synonyms: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-(4-Methylpiperazino)pyrimidine-5-boronic acid pinacol ester;2-(4-Methylpiperazin-1-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine;2-(4-methyl-1-piperazinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
• CAS NO: 942922-07-8
• Molecular Formula: C₁₅H₂₅BN₄O₂
• Molecular Weight: 304.2
• Product Categories: Organoborons;Pyrimidine
• Mol File: 942922-07-8.mol

Chemical Properties

• Boiling Point: 445.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.44±0.42(Predicted)
• CAS DataBase Reference: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(942922-07-8)
• EPA Substance Registry System: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(942922-07-8)

Safety Data

• Hazardous Substances Data: 942922-07-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows for participation in Suzuki-Miyaura cross-coupling reactions and other synthetic methodologies, facilitating the creation of diverse and complex molecular structures with potential therapeutic applications.
Used in Drug Discovery Research:
In the field of drug discovery, 2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is utilized as a key component in the design of novel biologically active molecules. The presence of the 4-methylpiperazine group indicates its potential to interact with various biological targets, such as receptors and enzymes, which can lead to the discovery of new drugs with improved efficacy and selectivity.
Used in Pharmaceutical Industry:
2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is employed as a valuable chemical building block in the pharmaceutical industry. Its versatility in synthetic methodologies and potential for biological target interactions make it an essential tool for the development of innovative therapeutic agents with diverse mechanisms of action.
Overall, 2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is a promising chemical compound with a wide range of applications in medicinal chemistry, drug discovery research, and the pharmaceutical industry, owing to its unique structure and potential for biological target interactions.

Upstream product

• 141302-36-5 5-bromo-2-(4-methylpiperazin-1-yl)pyrimidine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1092367-94-6 N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide 

Relevant articles and documents

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

ANTIBACTERIAL CONDENSED THIAZOLES

Compound of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; AIk - is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (-0-), thioether (-S-) or amino (-NR)- link, wherein R is hydrogen, -CN or C1-C3 alky!; X is -C(=O)NR6-, or -C(=O)O- wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; Z1 is -N= or -CH= Z2 is -N= or -C(R1)=; R1 is hydrogen, methyl, ethyl, ethenyl, ethynyl, methoxy, mercapto, mercaptomethyl halo, fully or partially fluorinated (C1-C2)alkyl, (C1-C2JaIkOXy or (C1-C2)alkylthio, nitro, or nitrile (-CN); R2 is a group Q1 -[Alk1]q-Q2 -, wherein q is 0 or 1; AIkl is an optionally substituted, divalent, straight chain or branched C1-C6 alkylene, or C2-C6 alkenylene or C2-C6 alkynylene radical which may contain or terminate in an ether (-O-), thioether (-S-) or amino (-NR)- link; Q2 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms; Q1 is hydrogen, an optional substituent or an optionally substituted carbocyclic or heterocyclic radical having 3-7 ring atoms

AZAINDOLE INHIBITORS OF AURORA KINASES

The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including s