943250-66-6

Basic information

• Product Name: (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide
• Synonyms: (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide;Lopinavir EP impurity R
• CAS NO: 943250-66-6
• Molecular Formula: C47H58N4O7
• Molecular Weight: 790.98602
• Product Categories: Anti-virals, Chiral Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 943250-66-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide(943250-66-6)
• EPA Substance Registry System: (αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide(943250-66-6)

Safety Data

• Hazardous Substances Data: 943250-66-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(αS)-3-[2-(2,6-DiMethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-diMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetaMide is used as an impurity reference for quality control and assurance in the production of Lopinavir (L469480), a selective HIV protease inhibitor. Its presence in the final product needs to be monitored and controlled to ensure the safety, efficacy, and purity of the antiretroviral medication.
As an impurity reference, Lopinavir EP Impurity R aids in the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) and mass spectrometry, for the detection and quantification of related substances in Lopinavir. This helps in maintaining the quality standards set by regulatory agencies for pharmaceutical products, ultimately benefiting patients receiving treatment for HIV infection.