- Improved method for synthesizing L-thyroxine sodium
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The invention relates to an improved method for synthesizing L-thyroxine sodium. The improved method includes the steps that 3,5-diiodomethane-L-tyrosine is used as a raw material, and then subjectedto a copper complex reaction, a coupling reaction, an acid hydrolysis reaction, an iodine generation reaction and a salt forming reaction to obtained the L-thyroxine sodium. According to the improvedmethod for synthesizing the L-thyroxine sodium, the yield of the L-thyroxine sodium can be improved, the product cost is lowered, and industrialization is convenient.
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Paragraph 0041; 0047; 0048; 0049; 0050; 0066-0067; 0070-0071
(2019/06/11)
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- NOVEL PROCESS FOR THE PREPARATION OF LEVOTHYROXINE SODIUM
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The present invention provides a novel process for the preparation of highly pure Levothyroxine Sodium, i.e., (S)-2-amino-3-[4-(4-hydroxy-3, 5-diiodophenoxy)-3,5- diiodophenyl] propanoic acid sodium salt via two process intermediates viz 3,5-Diiodo L- Tyrosine copper complex and novel Bis (p-anisyl) iodonium lodide.The invention also provides levothyroxine pentahydrate free from genotoxic impurities and liothyronine levels below 0.04% wt/wt.
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Page/Page column 6; 7
(2015/02/19)
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