Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles
A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.
Oxone-mediated facile access to substituted pyrazoles
An Oxone-mediated transition-metal-free oxidative C-N bond formation has been achieved for the regioselective synthesis of substituted pyrazoles. The reactions accompany the chelation-controlled ortho-oxidation of N-substituted aromatic ring to provide ph
Thermolysis of Polyazapentadienes. Part 7. An Unambiguous Route to 7-Substituted Quinolines from Cinnamaldehyde Derivatives
Flash vacuum pyrolysis of the cinnamaldehyde phenylhydrazone derivatives (4) - (6) or O-alkyl oxime derivatives (7) - (12) at 600 -650 deg C and 10-2 - 10-3 Torr leads to approximately equal quantities of cinnamonitriles and quinolines.Use of a p-substituted cinnamaldehyde derivatives gives the appropriate 7-substituted quinoline in high isomeric purity; the reactions take place via conjugated iminyl radicals.
Hickson, Clare L.,McNab, Hamish
p. 1569 - 1572
(2007/10/02)
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