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943924-39-8

NB-972 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 943924-39-8 Structure

  • Basic information

    1. Product Name: NB-972
    2. Synonyms: (4S)-4-[(1R)-1-Hydroxy-2-[[1-(3-isopropylphenyl)cyclopropyl]amino]ethyl]-19-(methoxymethyl)-11,16-dioxa-3,18-diazatricyclo[15.3.1.16,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one;
    3. CAS NO:943924-39-8
    4. Molecular Formula: C34H43N3O5
    5. Molecular Weight: 573.733
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 943924-39-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 786.4±60.0 °C (760 mmHg)
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.22±0.1 g/cm3 (20 °C, 760 mmHg)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: NB-972(CAS DataBase Reference)
    10. NIST Chemistry Reference: NB-972(943924-39-8)
    11. EPA Substance Registry System: NB-972(943924-39-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 943924-39-8(Hazardous Substances Data)

943924-39-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 943924-39-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,3,9,2 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 943924-39:
(8*9)+(7*4)+(6*3)+(5*9)+(4*2)+(3*4)+(2*3)+(1*9)=198
198 % 10 = 8
So 943924-39-8 is a valid CAS Registry Number.

943924-39-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 11,16-Dioxa-3,18-diazatricyclo[15.3.1.16,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one, 4-[(1R)-1-hydroxy-2-[[1-[3-(1-methylethyl)phenyl]cyclopropyl]amino]ethyl]-19-(methoxymethyl)-, (4S)-

1.2 Other means of identification

Product number -
Other names (4S)-4-[(1R)-1-Hydroxy-2-[[1-(3-isopropylphenyl)cyclopropyl]amino]ethyl]-19-(methoxymethyl)-11,16-dioxa-3,18-diazatricyclo[15.3.1.16,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:943924-39-8 SDS

943924-39-8Upstream product

943924-39-8Downstream Products

943924-39-8Relevant articles and documents

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Lerchner, Andreas,Machauer, Rainer,Betschart, Claudia,Veenstra, Siem,Rueeger, Heinrich,McCarthy, Clive,Tintelnot-Blomley, Marina,Jaton, Anne-Lise,Rabe, Sabine,Desrayaud, Sandrine,Enz, Albert,Staufenbiel, Matthias,Paganetti, Paolo,Rondeau, Jean-Michel,Neumann, Ulf

scheme or table, p. 603 - 607 (2010/06/19)

A series of macrocyclic peptidic BACE-1 inhibitors was designed. While potency on BACE-1 was rather high, the first set of compounds showed poor brain permeation and high efflux in the MDRI-MDCK assay. The replacement of the secondary benzylamino group wi

MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS

-

Page/Page column 32, (2008/06/13)

The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

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