Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists
Vasopressin 1b (V1b) antagonists have been postulated as possible treatments for depression and anxiety. A novel series of potent and selective V1b antagonists has been identified starting from an in-house screen hit. The incorporation of a sulfonamide li
Scott, Jack D.,Miller, Michael W.,Li, Sarah W.,Lin, Sue-Ing,Vaccaro, Henry A.,Hong, Liwu,Mullins, Deborra E.,Guzzi, Mario,Weinstein, Jay,Hodgson, Robert A.,Varty, Geoffrey B.,Stamford, Andrew W.,Chan, Tin-Yau,McKittrick, Brian A.,Greenlee, William J.,Priestley, Tony,Parker, Eric M.
scheme or table
p. 6018 - 6022
(2010/06/16)
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors
γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther
Guo, Tao,Gu, Huizhong,Hobbs, Doug W.,Rokosz, Laura L.,Stauffer, Tara M.,Jacob, Biji,Clader, John W.
p. 3010 - 3013
(2008/02/05)
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