Synthesis and Dihydropteridine Reductase Inhibitory Effects of Potential Metabolites of the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a nigrostriatal neurotoxin which can cause irreversible parkinsonism in humans and primates by selective destruction of neurons in the substantia nigra.It is possible that MPTP could be metabolized by
Gessner, Wieslaw,Brossi, Arnold,Shen, Rong-sen,Abell, Creed W.
p. 311 - 317
(2007/10/02)
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