- Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A
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The potent antibiotic thiazolylpeptide GE2270 A was synthesized starting from N-tert-butyloxycarbonyl protected valine in a longest linear sequence of 20 steps and with an overall yield of 4.8 %. Key strategy was the assembly of the 2,3,6-trisubstituted p
- Delgado, Oscar,Martin Mueller,Bach, Thorsten
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experimental part
p. 2322 - 2339
(2009/04/10)
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- Thiazoles as inhibitors of 11B-hydroxysteroid dehydrogenase
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Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
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Page/Page column 16-17
(2008/06/13)
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