- Thieno[2,3-d]pyridazine cyclometalated iridium complex and preparation method thereof
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The invention discloses a thieno[2,3-d]pyridazine cyclometalated iridium complex and a preparation method thereof, belonging to the field of organic photoelectric materials. The thieno[2,3-d]pyridazine cyclometalated iridium complex provided by the invention overcomes the problems that an existing cyclometalated iridium complex is very sensitive to oxygen, and the quantum efficiency of the existing pyridazine iridium complex is not high. The preparation method comprises the following steps: synthesizing a monochloro-substituted thieno[2,3-d]pyridazine intermediate through a four-step reaction;mixing the monochloro-substituted thieno[2,3-d]pyridazine intermediate with substituted phenol, substituted thiophenol, substituted aniline or substituted carbazole active hydrogen-containing compounds dissolved in an organic solvent, adding alkali, and carrying out a reaction to generate thieno[2,3-d]pyridazine ligand; and mixing the obtained thieno[2,3-d]pyridazine ligand with iridium trichloride and a solvent, and carrying out a reaction for a period of time to obtain the thieno[2,3-d]pyridazine cyclometalated iridium complex.
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Paragraph 0098-0101
(2020/07/15)
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- Coupling of aromatic aldehydes with aryl halides in the presence of nickel catalysts with diazabutadiene ligands
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Nickel catalysts with diazabutadiene ligands promote cross-coupling of benzaldehydes with aryl halides in the presence of zinc as reducing agent, which leads to the corresponding benzhydrols and benzophenones. The benzophenone percentage considerably increases when lithium chloride additive is used.
- Asachenko,Valaeva,Kudakina,Uborsky,Izmer,Kononovich,Voskoboynikov
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p. 456 - 463
(2017/03/08)
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- Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors
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A series of pyrazolo[3,4-d]pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl group at the N-1 position and the hydrophobic diarylmethyl group at the piperazine largely influenced the in vitro antienteroviral activity of this new class of potent antiviral agents. It was found that the pyrazolo[3,4-d]pyrimidines with a thiophene substituent, such as compounds 20-24, in general exhibited high activity against coxsackievirus B3 (IC50=0.063-0.089μM) and moderate activity against enterovirus 71 (IC50=0.32-0.65μM) with no apparent cytotoxic effect toward RD (rhabdomyosarcoma) cell lines (CC5025μ M).
- Chern, Jyh-Haur,Shia, Kak-Shan,Hsu, Tsu-An,Tai, Chia-Liang,Lee, Chung-Chi,Lee, Yen-Chun,Chang, Chih-Shiang,Tseng, Sung-Nien,Shih, Shin-Ru
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p. 2519 - 2525
(2007/10/03)
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