945526-43-2 Usage
Uses
Used in Pharmaceutical Industry:
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]is used as a pharmaceutical agent for its ability to inhibit the in vitro phosphorylation of c-Kit. This inhibition can be beneficial in the development of treatments for conditions related to the overactivity of c-Kit, such as certain types of cancer.
Used in Cancer Research:
In cancer research, [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]is used to study the effects of inhibiting SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. This research can help in understanding the role of c-Kit in melanoma development and progression, potentially leading to the discovery of new therapeutic strategies for melanoma treatment.
Biological Activity
isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells.
in vitro
previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1].
in vivo
to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1].
references
[1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007).
Check Digit Verification of cas no
The CAS Registry Mumber 945526-43-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,5,2 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 945526-43:
(8*9)+(7*4)+(6*5)+(5*5)+(4*2)+(3*6)+(2*4)+(1*3)=192
192 % 10 = 2
So 945526-43-2 is a valid CAS Registry Number.
945526-43-2Relevant articles and documents
PHENYL IMIDAZOL SULFONAMIDE DERIVATIVES, THE PREPARATION METHOD THEREOF AND THE WHITENING COSMETIC COMPOSITION CONTAINING THE SAME
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Page/Page column 9, (2008/06/13)
The present invention relates to phenyl imidazol sulfonamide derivatives expressed by the above formula I and a method for producing the same, and a whitening cosmetic composition comprising the same. More particularly, the phenyl imidazol sulfonamide der
