- Pteridines, LXXV. - Synthesis and Properties of Biopterin and Biopterin Analogs
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The synthesis of biopterin (6), its 2-N,N-dimethyl- (8) and 4-thioxo derivative (19) as well as biolumazine (7) is described.The side chain of biopterin can be modified by reaction of α-acetoxy-isobutyryl chloride to yield 6-(L-threo-2-acetoxy-1-chloropropyl)pterin (10), which can be used as a starting material for further derivatisations. 2,1',2'-Triacylbiopterins (14, 16) possess a hydrolytically labile N-acyl group.The newly synthesized compounds were characterized by pK-determinations, UV, and NMR spectra.
- Kappel, Mathias,Mengel, Rolf,Pfleiderer, Wolfgang
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p. 1815 - 1825
(2007/10/02)
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