947404-33-3 Usage
Uses
Used in Pharmaceutical Research:
3-(4-Methoxy-benzyl)-2,4-dioxo-1,3,4,5,7,8-hexahydro-2H-pyrido[4,3-d]pyriMidine-6-carboxylicacidtert-butylester is used as a building block in pharmaceutical research for the synthesis of various drug compounds. Its unique chemical structure and functional groups make it a promising candidate for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(4-Methoxy-benzyl)-2,4-dioxo-1,3,4,5,7,8-hexahydro-2H-pyrido[4,3-d]pyriMidine-6-carboxylicacidtert-butylester serves as a versatile intermediate for the preparation of a wide range of organic compounds. Its tert-butyl ester group can be selectively removed under mild conditions, allowing for the introduction of various functional groups and the formation of diverse molecular architectures.
Used in Drug Development:
3-(4-Methoxy-benzyl)-2,4-dioxo-1,3,4,5,7,8-hexahydro-2H-pyrido[4,3-d]pyriMidine-6-carboxylicacidtert-butylester is used as a key intermediate in the development of new drugs. Its unique structure and functional groups can be exploited to design and synthesize novel pharmaceutical agents with improved potency, selectivity, and pharmacokinetic properties. 3-(4-Methoxy-benzyl)-2,4-dioxo-1,3,4,5,7,8-hexahydro-2H-pyrido[4,3-d]pyriMidine-
6-carboxylicacidtert-butylester has the potential to contribute to the discovery of innovative therapeutics for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 947404-33-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,4,0 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 947404-33:
(8*9)+(7*4)+(6*7)+(5*4)+(4*0)+(3*4)+(2*3)+(1*3)=183
183 % 10 = 3
So 947404-33-3 is a valid CAS Registry Number.
947404-33-3Relevant articles and documents
Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists
Lanier, Marion C.,Feher, Miklos,Ashweek, Neil J.,Loweth, Colin J.,Rueter, Jaimie K.,Slee, Deborah H.,Williams, John P.,Zhu, Yun-Fei,Sullivan, Susan K.,Brown, Michael S.
, p. 5590 - 5603 (2008/03/15)
The present article describes a selection of a new class of small molecule antagonists for the h-GnRH receptor, their preparation, and evaluation in vitro. Three computational methods were combined into a consensus score, to rank order virtual templates. The top 5% of templates were further evaluated in silico and assessed for novelty and synthetic accessibility. The tetrahydropyrido[4,3-d]pyrimidine-2,4-dione core was selected for synthesis and evaluated in vitro. Using an array approach for analog design and synthesis, we were able to drive the binding below 10 nM for the h-GnRH receptor after two rounds of optimization.
