947689-26-1

Basic information

• Product Name: N-(2-iodo-4-methoxyphenyl)acetamide
• Synonyms: N-(2-iodo-4-methoxyphenyl)acetamide
• CAS NO: 947689-26-1
• Molecular Weight: 291.088
• Mol File: 947689-26-1.mol

Chemical Properties

• CAS DataBase Reference: N-(2-iodo-4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-iodo-4-methoxyphenyl)acetamide(947689-26-1)
• EPA Substance Registry System: N-(2-iodo-4-methoxyphenyl)acetamide(947689-26-1)

Safety Data

• Hazardous Substances Data: 947689-26-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 191348-14-8 2-iodo-4-methoxylaniline 
• 104-94-9 4-methoxy-aniline 
• 51-66-1 4-methoxyacetanilide 

Downstream Products

• 79044-03-4 2-ethenyl-4-methoxyacetanilide 
• 2941-72-2 6-methoxy-2-methylbenzothiazole 
• 1440546-92-8 N-(4-methoxy-2-((trimethylsilyl)ethynyl)phenyl)acetamide 
• 181306-01-4 1-(5-methoxy-2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 765272-15-9 N-acetyl-4-methoxy-2-(1-pentynyl)-N-methylaniline 
• 947689-04-5 C₂₈H₃₀NO₇P 
• 765272-47-7 N-(2-iodo-4-methoxy-phenyl)-N-methyl-acetamide 

Relevant articles and documents

Synthesis of 2,3-Disubstituted Indoles and Benzofurans by the Tandem Reaction of Rhodium(II)-Catalyzed Intramolecular C-H Insertion and Oxygen-Mediated Oxidation

A highly effective and straightforward method to construct a wide range of functionalized 2,3-disubstituted indoles has been developed. The method involves the tandem reaction of rhodium(II)-catalyzed denitrogenative annulation of triazole-based benzyl an

Cobalt(II)-catalyzed regioselective C-H halogenation of anilides

A cobalt-catalyzed regioselective C-H halogenation methodology is reported herein. The highlight of this work is the highly selective C-H functionalization of anilides, which results in high-yielding, versatile, and practical halogenated products. Thereby, brominations, chlorinations and iodinations of many electron-rich and electron-deficient anilides were achieved in a highly selective fashion. Mechanistic studies with respect to the pathway of the reaction are also described.

Monoprotected l-Amino Acid (l-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)?H Bonds by Iridium(III) Catalysis

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected l-amino acid (l-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp2)?H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.

Intramolecular C-N bond addition of amides to alkynes using platinum catalyst

The intramolecular aminoacylation of alkynes using ortho-alkynylacetanilides proceeds in very high yields in the presence of PtCl2 catalyst. This reaction provides not only a useful procedure for synthesizing 2,3-disubstituted indoles at once from ortho-alkynylaniline derivatives, but also an interesting mechanistic aspect; the intramolecular C-N bond addition of amides to alkynes takes place readily in the presence of Pt(II) catalyst. Copyright