948718-97-6Relevant articles and documents
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
Cai, Jiaqiang,Robinson, John,Belshaw, Simone,Everett, Kathryn,Fradera, Xavier,Van Zeeland, Mario,Van Berkom, Leon,Van Rijnsbergen, Peter,Popplestone, Lucy,Baugh, Mark,Dempster, Maureen,Bruin, John,Hamilton, William,Kinghorn, Emma,Westwood, Paul,Kerr, Jennifer,Rankovic, Zoran,Arbuckle, Wullie,Bennett, D. Jonathan,Jones, Philip S.,Long, Clive,Martin, Iain,Uitdehaag, Joost C.M.,Meulemans, Tommi
scheme or table, p. 6890 - 6894 (2011/02/25)
The trifluoromethylphenyl P2 motif from previously reported heteroarylnitrile series has been successfully applied for the design and synthesis of highly potent novel ketoamide-based cathepsin S inhibitors. The key in this process is the change of the tor
