- Iron-mediated total synthesis of 2,7-dioxygenated carbazole alkaloids
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We describe the efficient iron-mediated total synthesis of clausine O, clausine H (clauszoline-C) and anti-HIV active 7-methoxy-O-methylmukonal and clausine K (clauszoline-J). Consecutive C-C and C-N bond formations between 3-methoxy-4-methylaniline and a cyclohexadienyliumiron complex salt afforded 2,7-dimethoxy-3-methylcarbazole, which served as common intermediate en route to the four alkaloids. Four 2,7-dioxygenated carbazole alkaloids, clausine O, clausine H (clauszoline-C), and the anti-HIV active 7-methoxy-O-methylmukonal and clausine K (clauszoline-J), have been synthesized by using an iron-mediated approach for the construction of the carbazole framework. Copyright
- Krahl, Micha P.,Kataeva, Olga,Schmidt, Arndt W.,Knoelker, Hans-Joachim
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