Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors
Plasmodium falciparum lactate dehydrogenase (pfLDH) is a key enzyme for energy generation of malarial parasites and is a potential antimalarial chemotherapeutic target. It is known that the oxamate moiety, a pyruvate analog, alone shows higher inhibition
Choi, Seoung-Ryoung,Pradhan, Anupam,Hammond, Nicholas L.,Chittiboyina, Amar G.,Tekwani, Babu L.,Avery, Mitchell A.
p. 3841 - 3850
(2008/02/11)
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