- 1,2,3-triazole structure containing enol ether compounds as antifungal agent
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The invention discloses 1,2,3-triazole structure containing enol ether compounds shown in a formula (I) or pharmaceutically acceptable salts, solvates, optical isomers or polymorphic substances thereof. X is N or CH; R1 and R2 are H atoms, halogen, nitro, cyano, C1-C6 alkyl and halogenated C1-C6 alkyl, and R1 and R2 can be the same or different; R3 and R4 are H atoms, halogen, hydroxyl, an amino group, a cyano group, nitro, halogenated C1-C6 alkyl, C1-C6 alkyl, C6-C10 aryl, C4-C6 aromatic heterocyclic groups, C1-C6 alkoxy and halogenated C1-C6 alkoxy; R3 and R4 can be the same or different. Asthe antifungal agent, the 1,2,3-triazole structure containing enol ether compounds have higher killing effects on clinically common pathogenic fungi and are expected to overcome the defects of largetoxic and side effects, high drug resistance probability and the like of azole antifungal drugs widely used clinically at present.
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Paragraph 0049; 0058; 0059
(2018/09/12)
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- Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
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Triazole antifungal agents of the formula STR1 where R is 5-chloropyrid-2-yl or phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF3, C1 -C4 alkyl and C1 -Csub
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