949572-70-7

Basic information

• Product Name: 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline
• Synonyms: 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline
• CAS NO: 949572-70-7
• Molecular Formula: C₁₈H₁₁N₅
• Molecular Weight: 297.31
• Mol File: 949572-70-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline(949572-70-7)
• EPA Substance Registry System: 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline(949572-70-7)

Safety Data

• Hazardous Substances Data: 949572-70-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline is used as a building block for the synthesis of more complex organic molecules, leveraging its unique structure and reactivity.
Used in Coordination Chemistry:
In coordination chemistry, 2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline is used as a ligand to form coordination complexes with metal ions, which can be important for various catalytic and sensing applications.
Used in Pharmaceutical Applications:
2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline is used as a potential active pharmaceutical ingredient, where its heterocyclic nature may contribute to its interaction with biological targets, such as enzymes or receptors.
Used in Chemical and Biological Sensing:
2-(Pyridin-4-yl)imidazo[4,5-f][1,10]phenanthroline is used as a sensing agent due to its luminescent and fluorescent properties, which can be exploited in the development of sensors for detecting various chemical and biological species.

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 27318-90-7 1,10-phenanthroline-5,6-dione 
• 66-71-7 1,10-Phenanthroline 
• 168646-54-6 1,10-o-phenanthroline-5,6-diamine 

Relevant articles and documents

Structural distortion controlled spin-crossover behavior

Two mononuclear isomorphous complexes Fe(L1)2(SCN)2 (1) and Fe(L2)2(SCN)2 (2) [L1 = 2-(pyridin-3-yl)-1H-imidazo[4,5-f]1,10-phenanthroline; L2 = 2-(pyridin-4-yl)-1H-imidazo[4,5-f]1,10-phenanthroline] were obtained based on 1,10-phenanthroline derivatives. Due to the different structural distortion in the coordination geometries, 1 exhibits gradual spin transition around room temperature (T1/2 = 315 K), while 2 displays a stable high-spin state.

Surface confined heteroleptic copper(ii)-polypyridyl complexes for photonuclease activity

Heteroleptic copper(II)-polypyridyl complexes with extended π-conjugated, aromatic terminal units were immobilized on glass/Si substrates to intercalate DNA and cleave it upon photoexposure. Photonuclease activity is shown to be high, well reproducible and non-destructible towards the assembled complexes.

Heteronuclear metal iridium-rhenium complex as well as preparation method and application thereof

The invention discloses a heteronuclear metal iridium-rhenium complex as well as a preparation method and application thereof. The heteronuclear metal iridium-rhenium complex enters cells in an energy-dependent way, selectively targets lysosome, has good anti-tumor activity on HeLa, HepG2, A549 and cis-platinum drug-resistant strain A549R cells, and induces apoptosis of tumor cells. Therefore, the compound can be used as an anti-tumor drug for targeting tumor lysosomes instead of traditional DNA (Deoxyribose Nucleic Acid).

HETEROAROMATIC IMIDAZOLYL COMPOUNDS AND METHODS FOR TREATING CANCER

Provided herein are heteroaromatic imidazolyl compounds, compositions comprising such compounds, and related methods of making and using the compounds, e.g., the compounds are useful for treating diseases such as cancer.

Heteroleptic Cu(II)-polypyridyl complexes as photonucleases

A series of heteroleptic Cu(ii)-polypyridyl complexes with terpyridine (3N)/imidazole (2N) backbones and appended with pyridyl, 2-naphthyl, 9-anthryl and 1-pyrenyl groups are synthesized and evaluated for their photonuclease activity. An array of techniques viz. UV-vis, fluorescence, circular dichroism and thermal denaturation established strong DNA binding affinity (Kb = ～104-106 M-1) and the binding modes were correlated with molecular docking studies. Photonuclease efficiency exceeded 90% for all the complexes under identical conditions. Interestingly, DNA binding propensity and photonuclease efficiency followed the increasing size, planarity, aromaticity, π-Stacking ability and hydrophobicity of the peripheral moiety.

Cationic, luminescent cyclometalated iridium(iii) complexes based on substituted 2-phenylthiazole ligands

Ten cationic heteroleptic iridium(iii) complexes, [Ir(emptz)2(N^N)](PF6) were prepared from a cyclometalated iridium bridged-chloride dimer involving two ethyl-4-methylphenylthiazole-5-carboxylate (emptz) ligands. One X-ray crystallo

Synthesis and evaluation of the europiumIII and zinc II complexes as luminescent bioprobes in high content cell-imaging analysis

Novel phenanthroline derivatives and their europium(III) and zinc(II) complexes have been prepared in up to 92%. In contrast to the stable zinc complexes, the europium compounds exhibit a strong luminescence in THF solution. However, quenching of the emis