951152-93-5

Basic information

• Product Name: 5-Pyrimidinecarboxaldehyde, 4-amino-6-(4-aminophenoxy)-, O-methyloxime
• Synonyms: 5-Pyrimidinecarboxaldehyde, 4-amino-6-(4-aminophenoxy)-, O-methyloxime
• CAS NO: 951152-93-5
• Molecular Formula: C12H13N5O2
• Molecular Weight: 259.26
• Mol File: 951152-93-5.mol

Chemical Properties

• Boiling Point: 456.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: 5-Pyrimidinecarboxaldehyde, 4-amino-6-(4-aminophenoxy)-, O-methyloxime(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxaldehyde, 4-amino-6-(4-aminophenoxy)-, O-methyloxime(951152-93-5)
• EPA Substance Registry System: 5-Pyrimidinecarboxaldehyde, 4-amino-6-(4-aminophenoxy)-, O-methyloxime(951152-93-5)

Safety Data

• Hazardous Substances Data: 951152-93-5(Hazardous Substances Data)

Upstream product

• 14160-93-1 4-amino-6-chloro-pyrimidine-5-carbaldehyde 
• 951152-76-4 4-amino-6-chloropyrimidine-5-carbaldehyde O-methyloxime 
• 123-30-8 4-amino-phenol 

Relevant articles and documents

4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II

A series of 4-aminopyrimidine-5-carbaldehyde oxime was discovered to have potent VEGFR-2 inhibitory activity. Described here are the chemistry for analogue synthesis and SAR study results. The PK properties, kinase profiling, and in vivo efficacy study for compound 4b are also discussed.

SUBSTITUTED PYRIMIDINE KINASE INHIBITORS

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.