2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride Ion-Mediated Generation of Functionalized Benzynes
2-[(Neopentyl glycolato)boryl]phenyl trifluoromethanesulfonates (triflates) and halides have been developed as new benzyne precursors, which generate benzynes at 120°C in the presence of a fluoride ion. There are two major features of these types of precu
GPR40 RECEPTOR AGONIST, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.
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Paragraph 1453-1456
(2014/05/24)
On the use of 2-(trimethylsilyl)iodobenzene as a benzyne precursor
A mild method for the generation of benzynes from 2-(trimethylsilyl) iodobenzene derivatives is reported. The employment of silver fluoride in conjunction with caesium fluoride is key for promoting useful levels of elimination and providing benzyne derived products in good yields. Moreover, the substrates are accessed by a novel alkynyl iodide cycloaddition.
Crossley, James A.,Kirkham, James D.,Browne, Duncan L.,Harrity, Joseph P. A.
scheme or table
p. 6608 - 6610
(2011/01/12)
An alkynylboronate cycloaddition strategy to functionalised benzyne derivatives
A new approach to benzyne precursors has been developed that involves the [4+2] cycloaddition of trimethylsilyl alkynylboronates with 2-pyrones, followed by oxidation and trifluoromethylsulfonylation of the boronate moiety. The Royal Society of Chemistry
Kirkham, James D.,Delaney, Patrick M.,Ellames, George J.,Row, Eleanor C.,Harrity, Joseph P. A.
supporting information; experimental part
p. 5154 - 5156
(2010/10/19)
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