9-alkylacridine synthesis using 2,2-dimethoxypropane as water scavenger
A rapid and high yielding green method was developed for acridine derivative synthesis in solvent free medium. The commercial reagents are easily converted into products by using of microwaves in a heterogeneous medium in the presence of zinc chloride and 2,2-dimethoxypropane. Principal advantages of the procedure are short time, low energy consumption, and easy work-up.
Bratulescu, George
p. 1877 - 1884
(2014/08/18)
Auto-tandem catalysis: Synthesis of acridines by Pd-catalyzed C=C bond formation and C(sp2)-N cross-coupling
A facile palladium-catalyzed synthesis of acridines has been realized by consecutive C=C double bond formation and C-N cross-coupling. A variety of functionalized acridines can be accessed from easily available o-dihalobenzenes and N-tosylhydrazones in a single operation. This one-pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine derivatives, which are generally difficult to synthesize by previously known methods.