- Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
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We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953). Comp
- Brasca, Maria Gabriella,Nesi, Marcella,Avanzi, Nilla,Ballinari, Dario,Bandiera, Tiziano,Bertrand, Jay,Bindi, Simona,Canevari, Giulia,Carenzi, Davide,Casero, Daniele,Ceriani, Lucio,Ciomei, Marina,Cirla, Alessandra,Colombo, Maristella,Cribioli, Sabrina,Cristiani, Cinzia,Della Vedova, Franco,Fachin, Gabriele,Fasolini, Marina,Felder, Eduard R.,Galvani, Arturo,Isacchi, Antonella,Mirizzi, Danilo,Motto, Ilaria,Panzeri, Achille,Pesenti, Enrico,Vianello, Paola,Gnocchi, Paola,Donati, Daniele
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p. 4998 - 5012
(2014/10/16)
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- PYRIDYL- AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE- AND FURANE-DERIVATIVES AS KINASE INHIBITORS
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The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R2, R3, R4, R5 and R6 are as defined in the specification. Further objects
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Page/Page column 48
(2008/06/13)
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