Substrate Controlled Regioselective Bromination of Acylated Pyrroles Using Tetrabutylammonium Tribromide (TBABr3)
Electrophilic bromination of pyrroles bearing carbonyl substituents at C-2 typically results in a mixture of the 4- and 5-brominated species, generally favoring the 4-position. Herein, we describe a substrate-controlled regioselective bromination in which
Gao, Shuang,Bethel, Travis K.,Kakeshpour, Tayeb,Hubbell, Grace E.,Jackson, James E.,Tepe, Jetze J.
p. 9250 - 9255
(2018/07/15)
Production of anticancer polyenes through precursor-directed biosynthesis
The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted pyrrole-2-carboxylates were synthesised
Clark, Benjamin R.,O'Connor, Stephen,Fox, Deirdre,Leroy, Jacques,Murphy, Cormac D.
experimental part
p. 6306 - 6311
(2011/10/10)
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