Reactions of alkyl radicals with oxime ether: One-pot synthesis of α- amino acids
The addition of water-resistant carbon radicals to glyoxylic oxime ether provided a new method for the one-pot synthesis of α-amino acids via a carbon-carbon bond formation. The reaction of 2-hydroxy-2-methoxyacetic acid methyl ester with benzyloxyamine a
Carbon radical addition to glyoxylic oxime ether via iodine atom-transfer process
Intermolecular carbon radical addition to glyoxylic oxime ether was effectively improved by using alkyl iodides and triethylborane which acts multiply as a Lewis acid, a radical initiator and a terminator. The addition of secondary and tertiary alkyl radi
One-pot synthesis of α-amino acids based on free radical-mediated carbon-carbon bond formation
The one-pot reaction of 2-hydroxy-2-methoxyacetic acid methyl ester with benzyloxyamine and an alkyl radical provided a convenient method for preparing the protected α-amino acids via a carbon-carbon bond formation by intermolecular carbon radical additio