952308-47-3

Basic information

• Product Name: 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one
• Synonyms: 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one;3,4-Dihydro-7-(4-iodobutoxy)-2(1H)-quinolinone;Aripiprazole IMpurity-E;7-(4-iodobutoxy)-3,4-dihydroquinolin-2(1H)-one
• CAS NO: 952308-47-3
• Molecular Formula: C13H16INO2
• Molecular Weight: 345
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 952308-47-3.mol

Chemical Properties

• Boiling Point: 469.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.560±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.41±0.20(Predicted)
• CAS DataBase Reference: 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one(952308-47-3)
• EPA Substance Registry System: 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one(952308-47-3)

Safety Data

• Hazardous Substances Data: 952308-47-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one is used as an impurity in the synthesis of Aripiprazole (A771000) for the development and production of this medication, which is utilized to treat mental/mood disorders.
Additionally, it is used as a degradation product in Aripiprazole tablets, which can impact the quality and efficacy of the medication over time. Monitoring and controlling the presence of this impurity is essential to ensure the safety and effectiveness of the final product.

Upstream product

• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 21261-76-7 N-(3-methoxyphenyl)-3-chloropropionamide 
• 536-90-3 m-Anisidine 
• 129722-34-5 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone 

Downstream Products

• 882880-12-8 7-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-oxy)butoxy)-3,4-dihydroquinoline-2(1H)-one 

Relevant articles and documents

Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes

The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications of the Catellani reaction, ipso-alkyl

Synthesis of novel 3,4-dihydroquinolin-2(1H)-one guanidines as potential antihypertensive agents

Hydroxy-3,4-dihydroquinolin-2(1H)-ones (4a-c) were synthesized by intramolecular Friedel Craft alkylation of N-(methoxyphenyl)-3- chloropropionamides (3a-c), obtained by acylation of anisidine with chloropropionyl chloride. The hydroxy-3,4-dihydro quinolin-2(1H)- ones (4a-c) were treated with various dibromo alkanes under phase transfer catalyst conditions at room temperature to give bromoalkyloxy- 3,4-dihydroquinolin-2(1H)- ones (5a-l) which on further reaction with guanidine hydrochloride in dimethyl formamide afforded N-{4- [(2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy]alkyl} guanidines (6a-l). These compounds were synthesized as potential antihypertensive agents.