cas 95233-32-2, 4-Benzyloxy-1-cyclohexanecarbonitrile (cis / trans mixture) | Articles data ｜lookchem

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95233-32-2

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SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl) ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers
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(2013/03/26)

PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR 119 G protein-coupled receptor modulator therapy. These novel compounds have the structure Formula I or Formula IA.
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Page/Page column 111

(2009/02/11)

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Chemical Properties

Boiling Point: 354.3±35.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
Solubility:Chloroform, Dichloromethane, Ethyl Acetate, Methanol
PSA: 33.02000
LogP: 3.28558

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