Novel self-immolative dendritic compounds which have a plurality of cleavable trigger units and hence can release a chemical moiety at their focal point upon a multi-triggering mechanism are disclosed. The novel self-immolative dendritic compounds are gated by a molecular logic gate, being either an AND or OR logic gate and hence can be beneficially used in a variety of biological, chemical and physical applications. Processes of preparing, compositions containing and methods utilizing the novel dendritic compounds are further disclosed.
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Page/Page column 22-23; sheet 2
(2010/11/24)
Self-immolative dendrimer biodegradability by multi-enzymatic triggering.
New self-immolative dendritic molecules have been designed and synthesized. The dendrons are built with a multi-enzymatic triggering mechanism, which initiates their biodegradation through a self-immolative chain fragmentation to release a reporter group
Amir, Roey J,Shabat, Doron
p. 1614 - 1615
(2007/10/03)
A SIMPLE METHOD FOR THE DIRECT BIS-ACYLATION THE PRIMARY AMINO GROUPS IN SPERMIDINE AND OTHER LINEAR TRIAMINES
A simple and efficient method for the direct symmetrical bis-acylation of spermidine and other linear triamines using acylimidazoles is described.By this procedure, the siderophore natural product N1,N8-bis(2,3-dihydroxybenzoyl) spermidine was synthesized in an overall yield of 70percent in two steps.
Joshua, Alummoottil V.,Scott, John R.
p. 5725 - 5728
(2007/10/02)
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