Spirocyclic Side-chain Derivatives of Penicillin and Cephalosporin
A series of two spirocyclic oxazolidinone derivatives of penicillin and four derivatives of cephalosporin have been prepared, as well as a benzoxazine conjugate of cephalosporin, with the object of freezing the conformation of the 6(7)-amide side-chain bearing a pendant aromatic ring.The antibacterial properties of these derivatives are discussed.
Sammes, Peter G.,Smith, Steven,Ross, Barry C.
p. 2117 - 2124
(2007/10/02)
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