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1H-Indazole, 5-bromo-7-iodo-, also known as 5-bromo-7-iodo-1H-indazole, is a chemical compound with the molecular formula C7H4BrIN2. It is a derivative of indazole, a heterocyclic aromatic organic compound. 1H-Indazole, 5-bromo-7-iodois a yellow solid at room temperature and is sparingly soluble in water. It is commonly used as a building block in organic synthesis and is known for its potential pharmacological activities. It has been studied for its use in the development of pharmaceutical drugs and as a substrate for various chemical reactions in the laboratory. Additionally, it has been investigated for its potential as a catalyst in organic reactions.

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  • 953410-86-1 Structure
  • Basic information

    1. Product Name: 1H-Indazole, 5-bromo-7-iodo-
    2. Synonyms: 1H-Indazole, 5-bromo-7-iodo-;5-Bromo-7-iodo-1H-indazole
    3. CAS NO:953410-86-1
    4. Molecular Formula: C7H4BrIN2
    5. Molecular Weight: 322.92853
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 953410-86-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 410.4±30.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 2.421±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 10.78±0.40(Predicted)
    10. CAS DataBase Reference: 1H-Indazole, 5-bromo-7-iodo-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1H-Indazole, 5-bromo-7-iodo-(953410-86-1)
    12. EPA Substance Registry System: 1H-Indazole, 5-bromo-7-iodo-(953410-86-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 953410-86-1(Hazardous Substances Data)

953410-86-1 Usage

Uses

Used in Organic Synthesis:
1H-Indazole, 5-bromo-7-iodois used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and functional groups make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Drug Development:
1H-Indazole, 5-bromo-7-iodois used as a starting material in the development of pharmaceutical drugs. Its potential pharmacological activities have been studied, and it has been investigated for its use in the treatment of various diseases and conditions.
Used in Chemical Reactions as a Substrate:
1H-Indazole, 5-bromo-7-iodois used as a substrate in various chemical reactions in the laboratory. Its reactivity and functional groups make it suitable for use in a wide range of reactions, including cross-coupling, substitution, and addition reactions.
Used in Catalyst Development:
1H-Indazole, 5-bromo-7-iodohas been investigated for its potential as a catalyst in organic reactions. Its unique properties and reactivity make it a promising candidate for the development of new and efficient catalytic systems in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 953410-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,4,1 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 953410-86:
(8*9)+(7*5)+(6*3)+(5*4)+(4*1)+(3*0)+(2*8)+(1*6)=171
171 % 10 = 1
So 953410-86-1 is a valid CAS Registry Number.

953410-86-1Downstream Products

953410-86-1Relevant articles and documents

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Knoepfel, Thomas,Nimsgern, Pierre,Jacquier, Sébastien,Bourrel, Marjorie,Vangrevelinghe, Eric,Glatthar, Ralf,Behnke, Dirk,Alper, Phil B.,Michellys, Pierre-Yves,Deane, Jonathan,Junt, Tobias,Zipfel, Géraldine,Limonta, Sarah,Hawtin, Stuart,Andre, Cedric,Boulay, Thomas,Loetscher, Pius,Faller, Michael,Blank, Jutta,Feifel, Roland,Betschart, Claudia

, p. 8276 - 8295 (2020/08/24)

Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual TLR7

ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

-

, (2018/09/21)

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES

-

, (2018/12/13)

The present invention relates to pyrazole fused-ring derivatives, their preparation methods, and use thereof in medicine. In particular, the present invention relates to a novel derivative represented by formula (I), and a pharmaceutically acceptable salt

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization

Harris, Christopher M.,Ericsson, Anna M.,Argiriadi, Maria A.,Barberis, Claude,Borhani, David W.,Burchat, Andrew,Calderwood, David J.,Cunha, George A.,Dixon, Richard W.,Frank, Kristine E.,Johnson, Eric F.,Kamens, Joanne,Kwak, Silvia,Li, Biqin,Mullen, Kelly D.,Perron, Denise C.,Wang, Lu,Wishart, Neil,Wu, Xiaoyun,Zhang, Xiaolei,Zmetra, Tami R.,Talanian, Robert V.

scheme or table, p. 334 - 337 (2010/04/02)

We describe structure-based optimization of a series of novel 2,4-diaminopyrimidine MK2 inhibitors. Co-crystal structures (see accompanying Letter) demonstrated a unique inhibitor binding mode. Resulting inhibitors had IC50 values as low as 19 nM and moderate selectivity against a kinase panel. Compounds 15, 31a, and 31b inhibit TNFα production in peripheral human monocytes.

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