954124-21-1

Basic information

• Product Name: 4-(4-Nitrophenyl)piperidine-2,6-dione
• Synonyms: 4-(4-Nitrophenyl)piperidine-2,6-dione;2,6-Piperidinedione, 4-(4-nitrophenyl)-
• CAS NO: 954124-21-1
• Molecular Formula: C₁₁H₁₀N₂O₄
• Molecular Weight: 234.21
• Mol File: 954124-21-1.mol

Chemical Properties

• Melting Point: 241-243 °C(Solv: ethanol (64-17-5))
• Boiling Point: 484.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.365±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.06±0.40(Predicted)
• CAS DataBase Reference: 4-(4-Nitrophenyl)piperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Nitrophenyl)piperidine-2,6-dione(954124-21-1)
• EPA Substance Registry System: 4-(4-Nitrophenyl)piperidine-2,6-dione(954124-21-1)

Safety Data

• Hazardous Substances Data: 954124-21-1(Hazardous Substances Data)

Upstream product

• 92289-14-0 3-(4-Nitro-phenyl)-pentanedioic acid 
• 79-22-1 methyl chloroformate 
• 954124-30-2 1-(4-methoxy-benzyl)-4-(4-nitro-phenyl)-piperidine-2,6-dione 
• 57-13-6 urea 

Downstream Products

• 954124-23-3 4-(4-amino-phenyl)-piperidine-2,6-dione 
• 1312808-99-3 1-(3-chloropropyl)-4-(4-nitrophenyl)piperidine-2,6-dione 
• 1312809-18-9 1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-4-(4-nitrophenyl)piperidine-2,6-dione 
• 1312809-17-8 1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-4-(4-nitrophenyl)piperidine-2,6-dione 
• 1312809-00-9 1-(4-chlorobutyl)-4-(4-nitrophenyl)piperidine-2,6-dione 

Relevant articles and documents

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α1-adrenoceptor subtypes

A number of new 4-phenylpiperidine-2,6-diones bearing at the 1-position an ω-[4-(substituted phenyl)piperazin-1-yl]alkyl moiety were designed and synthesized as ligands for the α1-adrenergic receptor (α1-AR) subtypes. Some synthesized compounds, tested in binding assays for the human cloned α1A-, α1B-, and α1D-AR subtypes, displayed affinities in the nanomolar range. Highest affinity values were found in derivatives having a butyl connecting chain between the 4-phenylpiperidine-2,6-dione and the phenylpiperazinyl moieties. 1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-4-phenylpiperidine-2,6- dione (34) showed the best affinity for the α1A-AR (pKi= 8.74) and 10-fold selectivity compared to the other two α1-AR subtypes. Some representative compounds were also tested in order to evaluate their effects on the signal transduction pathway coupled to α1-AR subtypes. They all blocked norepinephrine-induced stimulation of inositol phospholipid hydrolysis, thus behaving as antagonists. Binding data were used to refine a previously developed pharmacophoric model for α1D-ARs. The revised model shows a highly predictive power and could be useful for the future design of high affinity α1D-AR ligands.

Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors

During efforts to improve the bioavailability of FMS kinase inhibitors 1 and 2, a series of saturated and aromatic 4-heterocycles of reduced basicity were prepared and evaluated in an attempt to also improve the cardiovascular safety profile over lead ary

INHIBITORS OF C-FMS KINASE

The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, es