954224-17-0

Basic information

• Product Name: 3-(4-Chloro-phenoxymethyl)-azetidine
• Synonyms: 3-(4-Chloro-phenoxymethyl)-azetidine;3-[(4-Chlorophenoxy)methyl]azetidine HCl
• CAS NO: 954224-17-0
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.66138
• Mol File: 954224-17-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Chloro-phenoxymethyl)-azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chloro-phenoxymethyl)-azetidine(954224-17-0)
• EPA Substance Registry System: 3-(4-Chloro-phenoxymethyl)-azetidine(954224-17-0)

Safety Data

• Hazardous Substances Data: 954224-17-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
3-(4-Chloro-phenoxymethyl)-azetidine is used as a building block for synthesizing various biologically active compounds and pharmaceuticals. Its unique structure and reactivity make it a valuable component in creating complex organic molecules.
Used in Medicinal Chemistry:
CMAP is used as a building block for the development of new pharmaceuticals. Its ability to form carbon-carbon and carbon-heteroatom bonds allows for the creation of diverse drug candidates with potential therapeutic properties.
Used in Chemical Reactions:
3-(4-Chloro-phenoxymethyl)-azetidine is used as a reagent in chemical reactions, particularly for the formation of carbon-carbon and carbon-heteroatom bonds. This contributes to the synthesis of a wide range of chemical compounds.
Used in Therapeutic Applications:
CMAP is studied for its potential therapeutic applications in the treatment of various diseases, such as cancer and infectious diseases. Its unique properties and reactivity may contribute to the development of novel treatments and therapies.

Relevant articles and documents

HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor

HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vitro potency, but also in vivo efficacy in the mouse place recognition test. The advanced hit molecule 11 was further optimized by the elimination of the putatively mutagenic aromatic-amine building block that resulted in a novel, aminomethylindole compound family. The most balanced physico-chemical and pharmacological profile was found in case of compound 55. Docking study revealed an intersubunit binding site to be the most probable for our compounds. 55 demonstrated favorable cognitive enhancing profile not only in scopolamine-induced amnesia (place recognition test in mice) but also in natural forgetting (novel object recognition test in rats). Compound 55 was, furthermore, active in a cognitive paradigm of high translational value, namely in the rat touch screen visual discrimination test. Therefore, 55 was selected as a lead compound for further optimization. Based on the obtained favorable results, the invented aminomethylindole cluster may provide a viable approach for cognitive enhancement through positive allosteric modulation of α7 nAChRs.