954238-81-4

Basic information

• Product Name: (2-AMINO-3-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-AMINO-3-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl (2-aMino-3-chlorophenyl)carbaMate;CarbaMic acid, N-(2-aMino-3-chlorophenyl)-, 1,1-diMethylethyl ester;N1-Boc-3-chloro-1,2-benzenediamine;tert-Butyl (2-amino-3-chlorophenyl)
• CAS NO: 954238-81-4
• Molecular Formula: C11H15ClN2O2
• Molecular Weight: 242.71
• Mol File: 954238-81-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (2-AMINO-3-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-3-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(954238-81-4)
• EPA Substance Registry System: (2-AMINO-3-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(954238-81-4)

Safety Data

• Hazardous Substances Data: 954238-81-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
TBCA is utilized as a reagent in pharmaceutical synthesis, contributing to the development of new drugs and therapeutic agents. Its chemical properties make it a valuable component in the creation of various medicinal compounds.
Used in Chemical Research:
In the realm of chemical research, TBCA serves as a key reagent for studying enzyme inhibition and the underlying mechanisms of inflammatory and immune responses. Its role in this area aids in advancing our understanding of disease processes and potential treatment strategies.
Used in the Treatment of Neuroinflammatory and Neurodegenerative Disorders:
TBCA is explored for its potential therapeutic use in managing neuroinflammatory and neurodegenerative conditions. Its ability to inhibit PDE4 suggests that it may help in reducing inflammation and promoting neuroprotection, making it a promising candidate for further research and development in this field.
Used in Enzyme Inhibition Studies:
TBCA is employed in studies focused on enzyme inhibition, specifically targeting PDE4. This research is crucial for understanding the role of PDE4 in various physiological processes and identifying potential therapeutic targets for treating related diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, TBCA is of interest due to its potential as a lead compound for the development of new drugs. Its unique properties and ability to modulate enzyme activity make it a valuable asset in the search for effective treatments for a range of conditions.

Upstream product

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Relevant articles and documents

2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors

A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds 2n tightly bound FGFR4 with a Kd value of 3.3 nM and potently inhibited its enzymatic activity with an IC50 value of 2.6 nM, but completely spared FGFR1/2/3. The compound selectively suppressed proliferation of breast cancer cells harboring dysregulated FGFR4 signaling with an IC50 value of 0.38 μM. Furthermore, 2n exhibited extraordinary target specificity in a Kinome-wide screen against 468 kinases, with S(35) and S(10) selectivity scores of 0.01 and 0.007 at 1.0 μM, respectively.