955368-98-6

Basic information

• Product Name: 2-[4-(4-Amino-2-methylphenyl)-1-piperazinyl]-1-ethanol
• Synonyms: 2-[4-(4-Amino-2-methylphenyl)-1-piperazinyl]-1-ethanol
• CAS NO: 955368-98-6
• Molecular Formula: C13H21N3O
• Molecular Weight: 235.32534
• Mol File: 955368-98-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(4-Amino-2-methylphenyl)-1-piperazinyl]-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-Amino-2-methylphenyl)-1-piperazinyl]-1-ethanol(955368-98-6)
• EPA Substance Registry System: 2-[4-(4-Amino-2-methylphenyl)-1-piperazinyl]-1-ethanol(955368-98-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 955368-98-6(Hazardous Substances Data)

Usage

Properties

Contains a piperazine ring, an amino group, and an ethanol group

Uses

Commonly used in the pharmaceutical industry as an active ingredient in various medications

Effects

Known for its psychiatric and neurologic effects, often used as an antidepressant or anxiolytic agent

Mechanism of action

Increases levels of certain neurotransmitters in the brain to produce therapeutic effects

Handling

Should be used with caution and only under the guidance of a healthcare professional

Relevant articles and documents

PYRIDONE-SUBSTITUTED-DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE

The invention relates to a compound of general formula (I-0): wherein R1 means a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 mean a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, or a halo-C1-C6 alkoxy group; R6 means a hydrogen atom, or a C1-C6 alkyl group; R7a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6 alkyl group, -Q2-N(R1c)R1d or a nitrogen-containing heterocyclic group; R8a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6 alkyl group; or R7a and R8a form, as taken together, a C2-C6 alkylene group, or R7a and R8a and the ring atoms to which they bond may form a spiro ring or a bicyclo ring; and X and Y mean a methine group or a nitrogen atom. The compound of the invention has, based on its excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

Dihydropyrazolopyrimidinone derivatives

The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.