- LIPOXYGENASE INHIBITORS
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Various embodiments of the present disclosure are directed to compounds having Formula I, Formula II, Formula IIA, Formula III, Formula IIIA, Formula IIIB, and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases and/or treating associated diseases. In some embodiments, subject compounds are used to prepare a composition that is effective in treating neurodegenerative diseases.
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Paragraph 00609
(2021/07/02)
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- Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium-Sized Lactones and Lactams
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A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the n
- Lawer, Aggie,Rossi-Ashton, James A.,Stephens, Thomas C.,Challis, Bradley J.,Epton, Ryan G.,Lynam, Jason M.,Unsworth, William P.
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p. 13942 - 13947
(2019/08/28)
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- TARGETED TREATMENT OF LEIOMYOSARCOMA
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A method and medicament comprising 4,4,4-trifluoro-N-[(1S)-2-[[(7S)-5-(2- hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo- ethyl]butanamide or a pharmaceutically acceptable salt or hydrate thereof for treating leiomyosarcoma i
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- PHOTOCHROMIC THIENOCHROMENE COMPOUNDS
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The present invention relates to photochromic compounds, such as thienochromene compounds represented by the following Formulas (la) and/or (lb). The present invention also relates to photochromic compositions and articles containing one or more such phot
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Paragraph 0189
(2016/09/26)
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- NOTCH PATHWAY SIGNALING INHIBITOR COMPOUND
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The present invention provides a compound, or a pharmaceutically acceptable salt or hydrate, and a pharmaceutical composition containing said compound, or a pharmaceutically acceptable salt or hydrate, useful as a Notch pathway signaling inhibitor for the
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- One-pot synthesis of new aza- and diaza-aminophenanthrenes
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The synthesis of a series of benzo(iso)quinoline and phenanthroline derivatives has been achieved using an efficient one-pot procedure. It proceeds through a Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradia
- Rochais, Christophe,Yougnia, Rodrigue,Cailly, Thomas,Sopková-De Oliveira Santos, Jana,Rault, Sylvain,Dallemagne, Patrick
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experimental part
p. 5806 - 5810
(2011/08/09)
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- One-pot synthesis of novel poly-substituted phenanthrenes
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A one-pot synthesis of novel poly-substituted phenanthrenes is described in this article through a Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradiation. The selection of the appropriate starting materials allowed us to introduce diversity on various positions of the phenanthrene ring system.
- Yougnia, Rodrigue,Rochais, Christophe,Oliveira Santos, Jana Sopkovà-de,Dallemagne, Patrick,Rault, Sylvain
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experimental part
p. 2803 - 2808
(2010/06/16)
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- PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS
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The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmacuetical compositions are also encompassed
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