Structural Diversity-Oriented Synthesis of Orthogonally Protected Cyclic Amino Acid Derivatives with Multiple Stereogenic Centers
The synthesis of three-dimensional cyclopentane amino acid derivatives with multiple stereocenters and with high regiochemical and diastereochemical diversity has been achieved starting from cyclopentadiene-derived β-aminocyclopentenecarboxylic acid. The small-molecular design was based on stereo- and regiocontrolled functionalization of the starting cyclopentene β-amino acid through stereoselective oxirane formation/regioselective oxirane opening and resulted in regio- and diastereoisomers of novel orthogonally protected aminocyclopentanecarboxylates.
Diastereo- and enantioselective synthesis of orthogonally protected 2,4-diaminocyclopentanecarboxylates: A flip from β-amino- to β,γ-diaminocarboxylates
(Chemical Equation Presented) Conformationally restricted, orthogonally protected 2,4-diaminocarboxylates with a cyclopentane skeleton were efficiently synthesized from β-lactam 6, the syntheses involving strategies of diastereoselective epoxidation of th
Kiss, Lorand,Forro, Eniko,Sillanpaeae, Reijo,Fueloep, Ferenc
p. 8786 - 8790
(2008/03/13)
More Articles about upstream products of 959746-05-5