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96-42-4

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Synthesis and in-vitro activity of new 1β-methylcarbapenem derivatives as antibacterial agents
The synthesis of a new series of 1β-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in-vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime-pyrrolidine moiety showed the most potent antibacterial activity.
Jung, Myung-Ho,Joon, Hee Hong,Cho, Jung-Hyuck,Oh, Chang-Hyun
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p. 780 - 786
(2009/04/07)

Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying the greatest potency contain N-alkyl substituted piperidine and pyrrolidine rings spiro-fused to the α-carbon of the P1 residue.
Bekkali, Younes,Thomson, David S.,Betageri, Raj,Emmanuel, Michel J.,Hao, Ming-Hong,Hickey, Eugene,Liu, Weimin,Patel, Usha,Ward, Yancey D.,Young, Erick R.R.,Nelson, Richard,Kukulka, Alison,Brown, Maryanne L.,Crane, Kathy,White, Della,Freeman, Dorothy M.,Labadia, Mark E.,Wildeson, Jessi,Spero, Denice M.
p. 2465 - 2469
(2008/03/11)

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Chemical Properties

Boiling Point: 156 °C at 760 mmHg
Flash Point:79.9 °C
Density: 1.047 g/cm³
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Vapor Pressure: 2.94mmHg at 25°C
Refractive Index: 1.452
PKA: 7.42±0.20(Predicted)
PSA: 29.10000
LogP: -0.12240

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