- Solar-light driven photocatalytic conversion of p-nitrophenol to p-aminophenol on CdS nanosheets and nanorods
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A simple synthetic protocol devoid of toxic surfactants was applied for the synthesis of CdS nanosheets and nanorods by thermolyzing bis(4-benzylpiperadine-1-carbodithioate-κ2 S, S′) cadmium(II) (1) and propane-1,3-diyl bis (piperidincarbamodithioate)cadmium(II) (2) using ethylenediamine (en) as a solvent. The as obtained products were characterized by TEM, PXRD, and UV–Visible spectroscopy. The nanosheets (1) and nanorods (2) were confirmed by HR-TEM with a lattice spacing of 0.33?nm which corresponds to the 002 plane of hexagonal CdS, observations in consonance with XRD. Based upon the band gap obtained from UV–Vis, 2.91?eV (nanosheets) and 2.65?eV (nanorods), these nanoparticles (NPs) were used as solar light driven photocatalyst for the conversion of p-nitrophenol to p-aminophenol. The nanorods (8?min) were found slightly more efficient than nanosheets (10?min), and the conversion efficiency of both remained above 92% even after 3rd cycle without any structural damage as revealed by the afterward PXRD. The better catalytic activity of both morphologies can be attributed to quantum size effect and good optical absorbance.
- Khan, Azam,Rehman, Zia-ur-,Khan, Abdullah,Ambareen, Hina,Ullah, Haseeb,Abbas, Syed Mustansar,Khan, Yaqoob,Khan, Rajwali
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Read Online
- Synthesis method of heterocyclic compound containing bis (trimethylsilyl)
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The method comprises the following steps: first adopting bis (trichloromethyl) carbonate, ethylenediamine, an aqueous sodium hydroxide solution, chloroform and a supported catalyst to obtain 2 - imidazolidinone. Or, ethylenediamine, ethanol, distilled water, a supported catalyst, carbon disulfide and hydrochloric acid are prepared to obtain ethylene thiourea. The trimethylchlorosilane is dissolved in an organic solvent, ammonia gas is introduced, and heated to reflux until no white precipitate is generated and filtered to obtain the filtrate. The raw material 2 - imidazolidinone or ethylidene thiourea is then dissolved to obtain the raw material solution, ammonium sulfate is added, and the filtrate is added dropwise, heated and refluxed 5 - 6h, cooled to room temperature, filtered, and the product is obtained. The molar ratio of the raw material to the trimethyl chlorosilane is 1: (2.1 - 2.5), the quality of ammonium sulfate is 1.5 - 2% of the raw material. The preparation method is simple and high in yield.
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Paragraph 0047; 0052-0053; 0056; 0061-0062; 0071; 0073; ...
(2021/09/29)
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- AlCl3-Promoted Synthesis of 2-Mercapto Benzoheterocycles by Using Sodium Dimethyldithiocarbamate as Thiocarbonyl Surrogate
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A simple, expeditious and high-efficiency synthetic method for the AlCl3-mediated one-pot preparation of 2-mercapto benzoheterocycles (2-mercapto benzothiazoles, benzoxazoles and benzimidazoles) is described. By the treatment of a series of S, O and N heteroatoms containing bifunctional molecules with sodium dimethyldithiocarbamate in AlCl3, the desired benzoheterocycles are obtained smoothly. The protocol can also be applied on the synthesis of a series of thiazolidine-2-thiones, imidazolidine-2-thiones. This novel synthetic approach has advantages such as ligand-free, high efficiency, short reaction time, readily available starting materials and simple experimental procedures.
- Liu, Xing,Zhang, Shi-Bo,Dong, Zhi-Bing
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p. 5406 - 5411
(2018/10/20)
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- An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water
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An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.
- Liu, Xing,Liu, Min,Xu, Wan,Zeng, Meng-Tian,Zhu, Hui,Chang, Cai-Zhu,Dong, Zhi-Bing
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p. 5591 - 5598
(2017/12/06)
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- A new imidazoline-containing Bunte salt: Synthesis, molecular and electronic structure
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S-[(4,5-dihydro-1H-imidazol-2-yl)methyl]sulfothioate, a new imidazoline-containing Bunte salt 4 was prepared by reacting 2-chloromethylimidazoline 3 with sodium thiosulfate in aqueous solution at room temperature. The mechanism of the concerted SN2 reaction pathway was studied by means of quantum chemical calculations at the B3LYP/6-31G?? level of theory. The molecular structure of compound 4 incorporating a formal amidine moiety was confirmed by single crystal X-ray diffraction analysis, while its electronic structure was studied using quantum chemical calculations at the MP2/6-311++G?? level of theory.
- S?czewski, Franciszek,Gdaniec, Maria,Data, Krzysztof
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p. 359 - 363
(2017/10/25)
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- Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Construction
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An efficient and practical thiocarbonyl surrogate via combination of sulfur and chloroform has been developed. A variety of thiocarbamides and oxazolidinethiones have been established, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity. Meanwhile, pesticides Diafenthiuron (an acaricide), ANTU (a rodenticide), and Chloromethiuron (an insecticide) were practically synthesized through this method in gram scale. Dicholorocarbene, as the key intermediate, was further confirmed via a carbene-trapping control experiment.
- Tan, Wei,Wei, Jianpeng,Jiang, Xuefeng
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supporting information
p. 2166 - 2169
(2017/04/27)
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- Bis-(triethylphosphine)platinum(II) complexes with thiones as anti cancer agents
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Platinum(II) complexes having mixed ligands as anticancer agents. The central platinum atom is coordinated by two phosphine ligands and two heterocyclic thione ligands. Each heterocyclic thione ligand has a five-, six- or seven-membered heterocyclic ring with two nitrogen atoms at positions 1 and 3 of the ring and a thiocarbonyl group at position 2. Pharmaceutical compositions incorporated the platinum(II) complexes, methods of synthesizing the complexes and methods of treating cancers with the complexes or pharmaceutical compositions thereof are also described.
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Page/Page column 20
(2017/02/28)
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- Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands?in the presence of triethylphosphine
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Seven new platinum(II) complexes (1–7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR (1H, 13C & 31P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC50 values.
- Jomaa, Mohammed Yagoub,Altaf, Muhammed,Ahmad, Saeed,Bhatia, Gaurav,Singh, Jatinder,Altuwaijri, Saleh,Isab, Anvarhusein A.
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p. 787 - 795
(2017/10/13)
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- CdS nanocapsules and nanospheres as efficient solar light-driven photocatalysts for degradation of Congo red dye
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CdS-1 (nanosphers) and CdS-2 (nanocapsule), were synthesized via green synthetic route without using any toxic surfactants by thermolysis of bis(4-benzhydrylpiperazine-1-carbodithioate-κ2 S, S?)cadmium(II) (1) and bis (4-benzylpipera-zine-1-carbodithioate-κ2 S, S?)cadmium(II) (2), respectively in the presence of ethylenediamine as a solvent. The nanoparticles were characterized by TEM, XRD, SEM, FT-IR UV–Visible and Fluorescence spectroscopy. The TEM results showed the formation of nanospheres (CdS-1) and nanocapsules (CdS-2) from complexes 1 and 2, respectively. Both CdS nanoparticles (NPs) have hexagonal crystal phase and a band gap value in the visible region as confirmed by the XRD and UV–Visible spectra, respectively. The photoluminescence (PL) data revealed that CdS-2 has longer recombination time of photo-injected electron hole pairs than CdS-1. The similar FT-IR spectra for both CdS NPs, and different HOMO-LUMO gap values for complexes {4.8187?eV (1) and CdS-2 4.7504?eV (2)} as predicted by DFT calculations suggest that stability of complexes play a key role in controlling morphology. Furthermore, the visible light driven photocatalytic degradation of Congo red dye was observed higher for nanocapsules than nanospheres due to a longer recombination time of photo-injected electron hole pairs.
- Khan, Azam,Zia-ur-Rehman,Rehman, Muneeb-ur-,Khan, Rajwali,Zulfiqar,Waseem, Amir,Iqbal, Azhar,Shah, Zawar Hussain
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- A convenient synthesis of new annelated pyrimidines and their biological importance
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Several bicyclic/tricyclic-fused pyrimidines were synthesized from the reactions of amino esters and bifunctional nucleophiles such as 2-methylthio-thiazoline and 2-methylthio-imidazoline. The synthesized compounds were tested for their in vitro antimicrobial activities that revealed mild to moderate growth inhibitory potentials.
- Wahab Khan,Uddin, Mohammed Kabir,Ali, Morshed,Rahman, Mohammad S.,Rashid, Mohammad Abdur,Chowdhury, Rasheduzzaman
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p. E216-E221
(2014/11/07)
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- Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents
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The modulation of pro-inflammatory cytokines provides a target for controlling inflammatory diseases and attracts much attention in current anti-inflammatory drug development. Here, four series of thiazolidinone derivatives were synthesized and screened for anti-inflammatory activities. A majority of these compounds showed excellent inhibition on the expression of TNF-α and IL-6 in LPS-stimulated macrophages. Discussions are given regarding the structure-activity relationships. Compounds 12d and 12h inhibited LPS-induced TNF-α and IL-6 release in a dose-dependent manner. Furthermore, 12d exhibited a significant protection against LPS-induced septic death in mouse model. Together, these data present a series of new thiazolidinones with potential therapeutic effects in acute inflammatory diseases and they could be important leads in the continuing anti-inflammatory drug research.
- Hu, Jie,Wang, Yi,Wei, Xiaoyan,Wu, Xixi,Chen, Gaozhi,Cao, Gaozhong,Shen, Xueqian,Zhang, Xiuhua,Tang, Qinqin,Liang, Guang,Li, Xiaokun
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p. 292 - 301
(2013/07/11)
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- Synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole and imidazo [2, 1-b] thiazolo [5, 4-d] isoxazole derivatives
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In this work we describe the synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole derivatives. The reaction of 1, 2-diaminoethane 1 with carbon disulphide in H2O/ETOH as solvent furnishes 4, 5-dihydro-1H-imidazol- 2-thiol 2 under reflux condition. the reaction of 4, 5-dihydro-1H-imidazol-2- thiol on treatment with ethylchloro acetate and aromatic aldehyde in presence of anhydrous sodium acetate and acetic acid as solvent to give (Z)-2- (arylidene)-5, 6-dihydroimidazo [2, 1-b] [1, 3] thiazol-3 (2H)-one 3a-j. Compounds 3a-j was condensed with hydroxylamine to give 3- (aryl)-2, 3, 6, 7-tetrahydroimidazo [2, 1-b] [1, 3] thiazolo [5, 4-d] isoxazole 4a-j. The structures of the new compounds were established by elemental analyses, IR, 1H NMR and 13C NMR data.
- Jaberi, Hamid Reza,Noorizadeh, Hadi
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experimental part
p. 1518 - 1525
(2012/06/01)
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- Synthesis and DNA cleavage activity of 2-hydrazinyl-1,4,5,6-tetrahydropyrimidine containing hydroxy group
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2-Hydrazinyl-1,4,5,6-tetrahydropyrimidin-5-ol dihydrochloride 2, as well as 2-hydrazinyl-4,5-dihydro-1H-imidazole dihydrochloride 1, was synthesized as metal-free DNA cleaving agent. Agarose gel electrophoresis was used to assess the plasmid pUC 19 DNA cleavage activities in the presence of 1 and 2. DNA cleavage efficiency of 2 exhibits remarkable increases compared with its corresponding non-hydroxy compound 1. Kinetic data of DNA cleavage promoted by 2 fit to the Michaelis-Menten-type equation with kmax of 0.0378 ± 0.0013 h-1 giving 106-fold rate acceleration over uncatalyzed DNA. The acceleration is driven by the spatial proximity of the nucleophilic hydroxy group and the electrophilic activation for the phosphodiester by the ammonium and/or guanidinium groups. In vitro cytotoxic activities toward Hela cells and human leukemia HL-60 cells were also examined, and 2 exhibits stronger cytotoxic activities than 1.
- Shao, Ying,Ding, Yong,Jia, Zhao-Li,Lu, Xiao-Min,Ke, Zhi-Hong,Xu, Wei-Hong,Lu, Guo-Yuan
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scheme or table
p. 4274 - 4279
(2009/10/17)
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- Carbon tetrabromide promoted reaction of amines with carbon disulfide: Facile and efficient synthesis of thioureas and thiuram disulfides
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A novel carbon tetrabromide promoted one-pot reaction of amines and carbon disulfide under mild conditions has been developed, which provides a straightforward and efficient access to thioureas and thiuram disufides, depending on the nature of the amines employed. The promotion effect is explained as the transient formation of a sulfenyl bromide intermediate from dithiocarbamate and carbon tetrabromide during the reaction. Georg Thieme Verlag Stuttgart · New York.
- Liang, Fushun,Tan, Jing,Piao, Chengri,Liu, Qun
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experimental part
p. 3579 - 3584
(2009/07/04)
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- Synthesis, structure and transformations of 2-iminoimidazolidines into novel fused heterocyclic ring systems
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Reaction of 2-chloro-4,5-dihydroimidazole (1) with 2-aminobenzylamines (2a-d) afforded 2-[(imidazolidin-2-ylideneamino)methyl]-anilines (3a-d) which upon treatment with carbon disulfide gave 2,3-dihydro-12H-imidazo[2′,1′:4,5][1,3,5]thiadiazino[2,3-b]quinazolin-5-thiones (4a-d) and 3,4-dihydro-1H-quinazolin-2-thiones (5a-c). Analogous reaction of 1 with 2-aminobenzyl alcohol (6) led to the formation of [2-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl]methanol hydrochloride (7) which was transformed into 1-(4H-3,1-benzoxazin-2-yl)imidazolidin-2-thione (8).{A figure is presented}.
- Kornicka, Anita,Saczewski, Franciszek,Gdaniec, Maria
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p. 687 - 699
(2007/10/03)
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- Method of making imidazole-2-thiones
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The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.
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Page/Page column 9
(2008/06/13)
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- Ru(iv)-catalyzed isomerization of allylamines in water: A highly efficient procedure for the deprotection of N-allylic amines
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A general and efficient method for the deprotection of N-allylic substrates in aqueous media, using catalytic amounts of the bis(allyl)-ruthenium(iv) complexes [Ru(η3 : η2 : η3-C 12H18)Cl2] (1) and [{Ru(η3 : η-C10H16)(μ-Cl)Cl}2] (2), has been developed. The Royal Society of Chemistry 2005.
- Cadierno, Victorio,Garcia-Garrido, Sergio E.,Gimeno, Jose,Nebra, Noel
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p. 4086 - 4088
(2007/10/03)
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- Method of stabilizing alkylenebisdithiocarbamates
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A method of stabilizing an alkylenebis dithiocarbamate comprising contacting the alkylenebis dithiocarbamate with an inert gas, de-aerating the alkylenebis dithiocarbamate and packaging the alkylenebis-dithiocarbamate in an air-tight container.
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Page/Page column 2-3
(2008/06/13)
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- Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups
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New histamine H3-receptor antagonists were synthesised and tested on rat brain membranes and on electrically stimulated guinea-pig ileum. The new compounds have a central polar group represented by a 2-alkylimidazole or a 2-thioimidazoline nucleus. The effect of the polar group basicity on the optimal length of the alkyl chain, connecting this group to a 4(5)-imidazolyl ring, was investigated. The best affinity values, obtained by displacement of [3H]-RAMHA from rat brain, were obtained for the 2-alkylimidazole derivatives (2a-f) with tetramethylene chain (pK(i) 8.03-8.97), having an intermediate basicity between that of the previously reported 2- thioimidazoles (1a-i) and that of 2-alkylthioimidazolines (3a-h). In contrast, a general lowering of affinity (pK(i) 5.90-7.63) was observed for compounds of the last series (3a-h), with a complex dependence on the terminal lipophilic group and chain length. (C) 2000 Elsevier Science S.A.
- Mor, Marco,Bordi, Fabrizio,Silva, Claudia,Rivara, Silvia,Zuliani, Valentina,Vacondio, Federica,Morini, Giovanni,Barocelli, Elisabetta,Ballabeni, Vigilio,Impicciatore, Mariannina,Plazzi, Pier Vincenzo
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- 1-(Methyldithiocarbonyl)imidazole: A useful thiocarbonyl transfer reagent for synthesis of substituted thioureas
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1-(Methyldithiocarbonyl)imidazole 1 and its N-methyl quaternary salt 2 have been shown to be efficient methyldithiocarbonyl and thiocarbonyl transfer reagents for the synthesis of dithiocarbamates, symmetrical and unsymmetrical mono-, di- and tri-substituted thioureas in high yields under mild and simple non-hazardous reaction conditions. (C) 2000 Elsevier Science Ltd.
- Mohanta, Pramod K.,Dhar, Sanchita,Samal,Ila,Junjappa
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p. 629 - 637
(2007/10/03)
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- A cluster growth route to quantum-confined CdS nanowires
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Quantum-confined CdS nanowires with diameters around 4 nm and lengths ranging from 150 to 250 nm were grown for the first time from cadmium bis(diethyldithiocarbamate) [Cd(DDTC)2]2 by removal of the four thione groups with ethylenediamine (en) at 117°C for 2 min.
- Yan, Ping,Xie, Yi,Qian, Yitai,Liu, Xianming
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p. 1293 - 1294
(2007/10/03)
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- A Concise and Convenient Method for the Synthesis of Pure Substituted Thioureas
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Zinc dialkyldithiocarbamates offer excellent substrates for pure thioureas required for the ntifungal and X-ray crystallographic studies.
- Ramadas, K.,Janarthanan, N.
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p. 1101 - 1108
(2007/10/03)
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- Lac sulfur assisted synthesis of symmetrical thioureas
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This work presents a short and attractive method to synthesise a variety of 1,3-disubstituted symmetrical thioureas in high yields.
- Ramadas,Janarthanan,Velmathi
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p. 2255 - 2260
(2007/10/03)
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- Chiral auxiliaries and their use in the synthesis of chiral molecules
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Chiral imidazolidones and imidazolidinethiones having the general formula: STR1 where (a) Z is either oxygen or sulphur (b) the R groups are independently selected from hydrogen or R2 CO where R2 is C1 to C10 alkyl, C2 to C10 alkenyl or benzyl and (c) the two R1 groups are either (1) identical groups selected from C1 to C10 alkyl, phenyl or C1 to C6 alkyl or alkoxy substituted phenyl or (2) such that together they form an alkylene group of formula --(CH2)n -- where n=3 to 8. Most preferred are those compounds where both R groups are R2 CO and there is a C2 axis of symmetry running along the CZ double bond. Compounds of formula (I) where at least one R group is R2 CO are efficient chiral auxiliaries for a range of asymmetric electrophilic substitution reactions when used in homochiral form. As such they are important tools for synthesising a range of chiral pharmaceuticals, agrochemicals and the like.
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- REACTION OF 2-MERCAPTOBENZOTHIAZOLE WITH DIAMINES. SYNTHESIS OF O-AMINOBENZENETHIOL
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Heating of 2-mercaptobenzothiazole in an excess of hydrazine, ethylenediamine or propylenediamine leads to o-aminobenzenethiol.Moreover, with ethylenediamine, ethylenethiourea is isolated as secondary product.Successive addition-elimination steps rationalize these results. Key words: 2-mercaptobenzothiazole; o-aminobenzenethiol; hydrazine; diamines.
- Adelaere, Bruno,Masson, Serge,Vallee, Yannick,Labat, Yves
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p. 173 - 178
(2007/10/02)
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- Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 3. Guanidines
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The synthesis and anticonvulsant activity of a number of 2-aryl-5-guanidino-1,3,4 thiadiazoles are described.The unsubstituted guanidine 2a was found to possess potent anticonvulsant properties; considerable reduction or loss of activity however was observed with the majority of the substituted guanidines.Incorporation of the guanidine group into an imidazoline ring also resulted in a loss of activity.Secondary pharmacological evaluation confirmed the anticonvulsant properties of 2a but also revelated that the compound exibited a considerable degree of sedative activity.
- Chapleo, Christopher B.,Myers, Peter L.,Smith, Alan C. B.,Tulloch, Ian F.,Walter, Donald S.
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p. 951 - 954
(2007/10/02)
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- Synthesis and Transformations of 3-Benzoylimino-5,6-dihydro-3H-dithiazole>
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1-(N-benzoylthiocarbamoyl)-2-imidazolidinethione (3), obtained from 2-imidazolidinethione (1) and benzoyl isothiocyanate (2), was oxidized with hydrogen peroxide in acid solution to give the title compound (6A).Some transformations of 6A are reported.
- Saczewski, Franciszek,Foks, Henryk
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p. 751 - 753
(2007/10/02)
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- Stereospecific Synthesis of Some Novel cis-1-Aza Analogs of Cepham
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Annelation of N-acyl-2-thiomethyltetrahydropyrimidines (VII) with appropriate acid chlorides results in the formation of the corresponding β-methylthio-β-lactam (VIII) as single stereoisomer in each case.Treatment of these β-methylthio-β-lactams (VIII) with Ni in acetone yields stereospecifically the cis-1-azacepham analogs (IX).Application of a similar sequence of reactions on VIIf furnishes the novel 1-azacepham analog (XI) through a single step removal of the thiomethyl as well as the benzyloxycarbonyl groups from the intermediate β-lactam (X).Potassium carbethoxyacetonylglycinate (B) on treatment with the schiff base VIIa using POCl3/Et3N in CH2Cl2 gives the enamino-β-lactam (XII) which on exposure to HCl in ethanol yields the α-amino-β-lactam (XIV).Acylation of XIV with phenoxyacetyl chloride provides the α-amido-β-methylthio-β-lactam (XV).Raney-Ni desulphurisation of XII and XV affords ths cis-azacephams XIII and XVI respectively.
- Sharma, S. D.,Arora, S. K.,Mehra, Usha
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p. 895 - 901
(2007/10/02)
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- Applications of Phase Transfer Catalysis, 26. - Thioureas by Three-Component Reactions of Amines, Carbon Tetrachloride, and Sulfide Ions
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The title reactions proceed exothermically in the presence of a phase transfer catalyst.Thiophosgene is an intermediate in this conversion, and its phase transfer catalytic transformation into carbon disulfide and trithiocarbonate can be demonstrated.Perchloromethanethiol/sodium sulfide and a PT catalyst yield thiophosgene too.Activated vicinal dibromides were debrominated by Na2S/catalyst.
- Broda, Witold,Dehmlow, Eckehard V.
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p. 1839 - 1843
(2007/10/02)
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- A CONVENIENT METHOD FOR THE PREPARATION OF N,N'-DISUBSTITUTED THIOUREAS USING 2-CHLOROPYRIDINIUM SALT, SODIUM TRITHIOCARBONATE AND AMINES
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N,N'-Disubstituted thioureas were prepared in high yields by treating 2-chloropyridinium salt with sodium trithiocarbonate and subsequently adding amines.
- Takikawa, Yuji,Inoue, Noriyuki,Sato, Ryu,Takizawa, Saburo
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p. 641 - 642
(2007/10/02)
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- Comparative radioprotective activity of various pentagonal compounds with two heteroatomes
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Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.
- Robbe,Fernandez,Dubief,et al.
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p. 235 - 243
(2007/10/02)
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- Reactions of Cyanodithioformates with Primary Amines
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N-alkyldithiooxamides 3 and N,N-dialkyldithiooxamides 4 were synthesized in good yields by reaction of cyanodithioformates 1 with primary aliphatic amines.N-alkylcyanodithioformamides 2, intermediates in these reactions were obtained in very low yields only.The reaction of 1 and diaminoethane or 1,3-diaminopropane afforded imidazolidine-2-thione 5a respectively perhydropyrimidine-2-thione 5b.The reaction of 1 with 1-chloro-2-aminoethane did gave 2-thiocarbamoylthiazoline 7.
- Kibbel, H. U.,Kuecken, M.,Peters, E.,Weber, H.
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- 7-Alkylation and 7-Sulphonylation of 5,6-Dihydroimidazolo-thiazoles
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Reinvestigation of the alkylation of 3-phenyl-5,6-dihydroimidazolothiazole has shown that methylation occurs exclusively at the 7-position, and that the free base is readily solvolysed to a mixture of 1-methylimidazolidin-2-one, 1-methylimidazolidine-2-thione, and diphenacyl sulphide and disulphide. 3-Methyl-5,6-dihydroimidazolothiazole with methane- and arene-sulphonyl chlorides gave the corresponding 7-sulphonylthiazolium chlorides.On heating, these rearranged to 3-(2-chloroethyl)-4-methyl-3-aryl (or alkyl)sulphonylimido-2,3-dihydrothiazoles.The 7-(4-chlorophenylsulphonyl) derivative lost this substituent with aqueous base while concentrated aqueous ammonia attacked the 7a-position leading to a 3--2-imino-4-methyl-2,3-dihydrothiazole.
- Acheson, R. Morrin,Cooper, Martin W.,Cox, Ian R.
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p. 1773 - 1778
(2007/10/02)
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- 2-ARYL-1,3-THIAZETIDINES FROM ETHYLENE THIOUREA
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Several 2-aryl-1,3-thiazetidine derivatives were prepared by the condensation reaction of ethylene thiourea and aromatic aldehydes using boron trifluoride etherate.
- Yokoyama, Masataka,Monma, Hiromichi
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p. 293 - 296
(2007/10/02)
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- O-Ethyl Thiocarbamates. A Convenient Route to 2-Aryliminoimidazolidines
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The reaction of N-aryl thionocarbamates and ethylenediamine lead to the corresponding 2-aryliminoimidazolidines, whose structure in pharmacology is well known.But, the behaviour of the N-alkyl thionocarbamates is quite different under operative conditions and these compounds afford with ethylenediamine, to 2-(2'-aminoethylamino)-Δ2-imidazoline, according to a mechanism which is discussed.
- Reynaud, Pierre,Brion, Jean-Daniel,Davrinche, Catherine,Phan-Chi-Dao
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p. 1789 - 1792
(2007/10/02)
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- Pesticidal compositions containing phosphoric esters and divalent sulphur compounds
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Pesticidal composition comprising: a pesticidal, phosphoric ester the molecule of which has at least one alkyl group of 1 to 3 carbon atoms, 0.05 to 10% of an agent stabilizing the said ester against decomposition by protonisation, together with adjuvants characterized in that the stabilizing agent comprises at least one sulphur compound containing per molecule at least one divalent sulphur atom of which one valence is bonded to an atom chosen from sulphur, carbon, nitrogen, hydrogen, and metals capable of giving a salt, the other valence being bonded to an atom chosen from hydrogen, the carbon atom already noted, a second carbon atom, the nitrogen atom already noted, a second nitrogen atom, the metal atom already noted in the case of a metal of valence greater than one, a second atom of metal and oxygen when the first valence is not attached to an atom of hydrogen, the proportion of sulphur calculated with reference to the weight of the sulphur compound being between 5 and 99%. Process for stabilizing a phosphoric ester of which the molecule possesses at least one alkyl group containing 1 to 3 carbon atoms characterized in that there is added to the phosphoric ester or to a mixture which contains it, 0.05 to 10% calculated on the weight of the phosphoric acid ester of an agent capable of stabilizing the said phosphoric ester against protonisation and comprising at least one sulphur compound such as that defined thereupon.
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