- Synthesis method of prosulfuron intermediate
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The invention discloses a synthesis method of a prosulfuron intermediate 2-(3, 3, 3-trifluoropropyl) benzenesulfonamide, which comprises the following steps: by taking o-chlorobenzyl cyanide and ethyl trifluoroacetate as initial raw materials, firstly carrying out acylation reaction in the presence of organic alkali, then carrying out decyanation reaction in the presence of sulfuric acid, and then carrying out reduction reaction in the presence of a reducing agent, carrying out a dehydration reaction in the presence of a catalyst, carrying out a reduction reaction in the presence of a reducing agent, carrying out a sulfhydrylation reaction with a sulfhydrylation reagent, carrying out a sulfonyl chlorination reaction with chlorine in the presence of water, and carrying out a sulfonylation reaction with ammonia water. Compared with the prior art, the synthesis method has the advantages that the adopted raw materials and auxiliaries are low in cost and easy to obtain, the reaction conditions are mild, the operation is simple and convenient, the safety is higher, the synthesis method is more environment-friendly, the synthesis route is particularly important in the current times with stricter requirements on safety and environmental protection, and the safety of industrial production can be ensured.
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- Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
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The Friedel-Crafts reaction of 1,1,1-trifluoropropene with benzene and its derivatives was accomplished in the presence of fluorine-containing acid catalysts.The reaction proceeded at the terminal carbon atom of the olefin to give 3,3,3-trifluoropropylated aromatic compounds.The scope and limitations of this reaction were examined.This substituent was found to be ortho- and para-directing.Keywords - Friedel-Crafts reaction; trifluoropropene; trifluoropropyl; Nafion-H; hydrogen fluoride; boron trifluoride; tetrafluoroboric acid; benzene; trifluoropropylation
- Kobayashi, Yoshiro,Nagai, Takabumi,Kumadaki, Itsumaro,Takahashi, Masaaki,Yamauchi, Takashi
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p. 4382 - 4387
(2007/10/02)
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- Substituted benzene derivatives having at least one benzene ring substituted by 3,3,3-trifluoropropyl group and process for their production
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A novel trifluoropropyl derivative of mono-substituted benzene represented by the general formula: STR1 wherein R is halogen atom, trifluoromethyl, n-octyl, n-dodecyl, or phenoxy group not substituted or mono-substituted by 3,3,3-trifluoropropyl group, and n is an integer of 1, 2 or 3, with the proviso that the total number of 3,3,3-trifluoropropyl group of the derivative of mono-substituted benzene is at most 3, and a process for producing the derivative of mono-substituted benzene.
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