- Transition Metal-Free C-H Thiolation via Sulfonium Salts Using β-Sulfinylesters as the Sulfur Source
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We disclose a direct C(sp)-, C(sp2)-, and C(sp3)-H thiolation reaction using β-sulfinylesters as the versatile sulfur source. The key step of this protocol is chemoselective C-S bond cleavage of the sulfonium salts that are formed in situ from the corresponding alkenes, alkynes, and 1,3-dicarboxyl compounds with β-sulfinylesters. The successful capture of the acrylate byproduct supports a retro-Michael reaction mechanism.
- Chen, Yanhui,Wen, Si,Tian, Qingyu,Zhang, Yuqing,Cheng, Guolin
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p. 7905 - 7909
(2021/10/20)
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- Preparation method of thioether derivative
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The invention discloses a preparation method of a thioether derivative, which comprises the following steps: (1) in a nitrogen atmosphere, mixing a sulfoxide compound, an olefin compound/alkyne compound/1, 3-dicarbonyl compound, an organic solvent and trifluoroacetic anhydride/trifluoromethanesulfonic anhydride, and reacting at 0-60 DEG C for 1-24 hours; (2) adding alkali into the material obtained in the step (1), reacting at room temperature for 0.5-1.5 hours, and washing with water to obtain an organic phase; and (3) carrying out post-treatment and purification on the organic phase obtained in the step (2) to obtain the thioether derivative. The method is suitable for constructing alkenyl thioether, alkynyl thioether and alkyl thioether derivatives at the same time, and is high in universality. The method has the advantages of easily available raw materials, high yield, mild reaction conditions, short reaction time, wide substrate range, strong reaction specificity, and simple and green post-treatment.
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Paragraph 0038-0041
(2021/08/28)
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- Triaryl substituted alkenyl thioether compound synthesis method
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The invention mainly relates to a triaryl substituted alkenyl thioether compound synthesis method. Diaryl alkyne and thio-sulphonate serve as raw materials, difunctional reaction research on the alkyne is performed under the action of oxidizing agents, and a triaryl substituted alkenyl thioether compound is synthesized without metal. The synthesis method has the advantages that traditional metal for catalysis is omitted, a new path is provided for synthesis of the polysubstituted alkenyl thioether compound, a reaction system is simple, reaction equipment is less, experimental operation is simple and convenient, yield is above-average and the like.
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Paragraph 0076; 0077
(2019/04/17)
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