AN ENANTIOSELECTIVE APPROACH TO CARBAPENEM ANTIBIOTICS: FORMAL SYNTHESIS OF (+)-THIENAMYCIN
An enantioselective synthesis of intermediates in synthesis of thienamycin (15) and epithienamycin-C (16) is described.
Hart, David J.,Ha, Deok-Chan
p. 5493 - 5496
(2007/10/02)
Stereocontrolled total synthesis of the chiral building block (3S,4R)-3-[(R)-1-hydroxyethyl]-4-acetyloxy-azetidin-2-one: A useful synthon for the synthesis of (+)-thienamycin, carbapenems and penems
A total stereocontrolled synthesis of (1), an intermediate in the synthesis of (+)-thienamycin, carbapenems and penems, based on a strategy that uses the S(-)hydroxyethylbutyrate as chiral building block, is reported.
Cainelli,Contento,Giacomini,Panunzio
p. 937 - 940
(2007/10/02)
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