Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B
The inhibition of monoamine oxidase B (MAO-B) could be an effective approach for the treatment of various neurological disorders. In this study, a series of 1, 4-benzodioxan-substituted chalcone derivatives were designed, synthesised and evaluated for the
Kong, Zhuo,Sun, Demeng,Jiang, Yanmei,Hu, Yun
p. 1513 - 1523
(2020/07/30)
CHEMISTRY OF ISOFLAVONE HETEROANALOGS. 11. BENZODIOXANE ANALOGS OF CHALCONE, FLAVONE, AND ISOFLAVONE
Benzodioxane analogs of chalcones and their epoxides have been prepared.Different types of analogs of natural flavonolignan - silibin have been synthesized from these compounds.The PMR spectra of the new compounds and the results of the preliminary biological testings are reported and discussed.
Khilya, V. P.,Aitmambetov, A.,Turov, A. V.,Kornilov, A. M.,Litkei, D.,at al.
p. 149 - 154
(2007/10/02)
Synthesis of hypolipidemic silybin analog 3',4'-ethylenedioxyflavonoids