ANTIVIRAL COMPOUNDS FOR THE TREATMENT OF CORONAVIRUS, PICORNAVIRUS AND NOROVIRUS INFECTIONS
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating coronavirus, Picomavirus and Norovims infections with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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(2021/12/31)
Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines
"Chemical Equation Presented" Center stage: Additions of nitrogen-centered radicals to cyanamide compounds provided the first radical synthesis of aromatic polycyclic guanidine derivatives (see scheme). Modular assembly of the substrates allows for a rapid increase of the molecular complexity of scaffolds, which have potential applications for medicinal chemistry.
Koehler, Valentin,Bailey, Kevin R.,Znabet, Anass,Raftery, James,Helliwell, Madeleine,Turner, Nicholas J.
supporting information; experimental part
p. 2182 - 2184
(2010/06/18)
OXYDATION OF SECONDARY AMINES TO α-CYANOAMINES
The dehydrogenation of secondary amines with phenylseleninic anhydride or acid under mild conditions in the presence of either sodium cyanide or trimethylsilylcyanide gives good yields of α-cyanoamines.These compounds can be regarded as protected imines, or as a source of α-amino-acids.
Barton, Derek H. R.,Billion, Annick,Boivin, Jean
p. 1229 - 1232
(2007/10/02)
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